Difference between revisions of "UPICT"
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– clinical trial imaging protocols will “fit” with practice | – clinical trial imaging protocols will “fit” with practice | ||
• Potentially provide a subtle impetus to improve standard of care (thereby increasing the chances that pre-enrollment imaging might be used as “baseline” study) | • Potentially provide a subtle impetus to improve standard of care (thereby increasing the chances that pre-enrollment imaging might be used as “baseline” study) | ||
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+ | ==[[UPICT Process]] and [[UPICT Template|Template]]== | ||
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+ | ==Workspace and [[UPICT Template|Template]] Extractions in Progress== | ||
+ | * The Workspace is used to facilitate the submission,vetting and annotation of Proffered Protocols and the iterative authoring and periodic review of Consensus Protocols in a transparent and inclusive manner. | ||
+ | * The outline form of the generic [[UPICT Template|Template]] is posted. | ||
+ | * Web-based '''workspace''' and supporting infrastructure; multiple options are available | ||
+ | *The '''current work on template extractions''' is available here. [http://upictwiki.ctsa-imaging.org/index.php?title=Draft_Proffered_Protocols Link to '''Draft Proffered Protocols'''] | ||
==UPICT Objectives:== | ==UPICT Objectives:== |
Revision as of 20:34, 12 July 2012
UPICT Concept:
To facilitate the development and maintenance of widely acceptable, consistent imaging protocols (including imaging quality control procedures) for use in clinical trials across a range of disease states, anatomic sites, and imaging modalities:
• to “improve” the contribution of imaging data in clinical trials, including improved statistical power while supporting robust case accrual and decreasing time to study initiation / site activation • to facilitate image data aggregation across trials • to allow the development, optimization, and validation of imaging biomarkers through the participation of imaging scientists and clinical trialists drawn from the broad range of interested constituencies
UPICT Goals:
• Reduce variance related to imaging in the conduct of clinical trials (early and late phase so as to support both translation and clinical indications): – to allow the detection of differences that are a consequence of the intervention under study, not an artifact of the manner in which the imaging is conducted – to support optimization and validation of imaging biomarkers (platforms, agents, algorithms, etc.) • Improve the likelihood that: – clinical imaging studies obtained will comply with clinical trial protocol expectations – clinical trial imaging protocols will “fit” with practice • Potentially provide a subtle impetus to improve standard of care (thereby increasing the chances that pre-enrollment imaging might be used as “baseline” study)
UPICT Process and Template
Workspace and Template Extractions in Progress
- The Workspace is used to facilitate the submission,vetting and annotation of Proffered Protocols and the iterative authoring and periodic review of Consensus Protocols in a transparent and inclusive manner.
- The outline form of the generic Template is posted.
- Web-based workspace and supporting infrastructure; multiple options are available
- The current work on template extractions is available here. Link to Draft Proffered Protocols
UPICT Objectives:
• Short term – standard imaging protocol template(s) – a web-based workspace and supporting infrastructure to facilitate the submission, vetting, and annotation of Proffered Protocols in a transparent and inclusive manner – a web-based resource library of annotated Proffered Protocols that have been used to support clinical trials within institutions, cooperative groups, and trials consortia that meet a minimum set of criteria – a web-based workspace and infrastructure to facilitate the iterative authoring and periodic review of Consensus Protocols in a transparent and inclusive manner – a web-based environment to facilitate the interaction among clinical trialists and imaging scientists within academia, industry, and agencies • Long(er) term – a web-based resource library of Consensus Protocols that have been subjected to rigorous, transparent, inclusive (yet expert) review and approval that will be updated through an ongoing process