VolCT - Group 1B

Current Goals & Status:

Question: What is the minimum detectable level of change in patient datasets under a “No Change” condition?

• • AIMS: For patient datasets acquired over a very short time interval (“no change” condition”) investigate variance in measuring change in volume, diameter and bi-directional diameters of lesions
  • Investigate inter-observer variability in each task
  • Investigate Intra-observer variability in each task

• • Methods - Materials
    • Image Data from MSK Coffee Break Experiment
    • 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes
    • Thin slice (1.25 mm thick) image data
    • Selected one lesion per patient
    • no outcome data
    • Publicly Available on NCIA

• • Methods - Readings
    • 5 readers
    • Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability
  • Methods - Measurements
    • Measure Single Longest Diameter, manually (SLD)
    • Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD)
    • Contour Full Boundary of lesion with semiautomated tool; calculate volume (Vol)
    • Extract other measures as well (SLD from POD measureement; SLD from VOl and POD from Vol).
  • The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10)

• • Analyses
    • Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method
    • Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray

• Progress Reports
• QIBA CT Volumetrics,Group 1B:(Patient Image Datasets), 4.19.2011 - Dr. McNitt-Gray

• Analysis Reports
• Exp 1B Coffee Break Descriptive Statistics - 24Sep2010
• QIBA_Exp1B_Coffee Break Summary Table_26Jan11_RECIST_Measureable_or_NOT
• Exp 1B Coffee Break Descriptive Statistics - 25Mar2011_Subjective Assessments_EZ_mod_diff**
• QIBA_Exp1B_CoffeeBreak_summaryTable_minimum Detectable Change_ 18Apr2011

• Methods Related Documents
• QIBA_Exp1b_Coffee_Break_List of lesions with coordinates and pictures
• Naming Convention for the QIBA Group 1B Experiment and randomization scheme

• Vol-CT - 1B Group Call Summaries

• Other Related Documents
• Related Profile: Lung Vol Quantification - Measurement Activity

• Proposed Group 1B Questions & Datases (2009-02-10) -- Feedback Welcome -- Dr. McNitt-Gray
• ACRIN 6678 Quality Control Parameters for CT Scan Tumor Volumetric Measurements

• Conference Paper on Reproducibility and Accuracy of Uni- and Bi-Dimensional Tumor Measurements from MRI and CT Volumes, which looks at RECIST, WHO and Volume measurements.

Downloadable Images and Data Sets

Round 2 Images and Results

• TCIA RIDER Lung CT Images - Collection Description - Login, Search, Download - (MSKCC Coffee Break) - Used as No Change Cases link posted 12.29.2012
• NBIA RIDER Pilot CT Images - Collection Description - Login, Search, Download - Used as With Change Distractors link posted 12.29.2012
• DICOM Result Files (SR,SEG,PR) posted 12.29.2012
• Release notes describing collection contents posted 12.29.2012
• Description of SR encoding template posted 12.29.2012

• Excel File describing "No Change" cases (filenames, slice location, x,y coordinates, etc.) - [[Media:UCLA_CoffeeBreak_lesion_detailsv3-2_May_2011.xls]
• Excel File describing "Change" cases (filenames, slice location, x,y coordinates, etc.) - [Media:QIBA_1B_clinical_workflow_change_lesions_v2.xls]