Difference between revisions of "VolCT - Group 1B"
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==Current Goals & Status:== | ==Current Goals & Status:== | ||
− | * Question: What is | + | * Question: What is the minimum detectable level of change in patient datasets under a “No Change” condition? |
− | ** | + | ** AIMS: For patient datasets acquired over a very short time interval (“no change” condition”) investigate variance in measuring change in volume, diameter and bi-directional diameters of lesions |
− | ** | + | ** Investigate inter-observer variability in each task |
− | ** | + | ** Investigate Intra-observer variability in each task |
− | *** | + | |
− | *** | + | ** Methods - Materials |
− | *** | + | *** Image Data from MSK Coffee Break Experiment |
− | *** | + | *** 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes |
+ | *** Thin slice (1.25 mm thick) image data | ||
+ | *** Selected one lesion per patient | ||
*** no outcome data | *** no outcome data | ||
*** Publicly Available on NCIA | *** Publicly Available on NCIA | ||
+ | |||
+ | ** Methods - Readings | ||
+ | *** 5 readers | ||
+ | *** Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability | ||
+ | ** Methods - Measurements | ||
+ | *** Measure Single Longest Diameter, manually (SLD) | ||
+ | *** Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD) | ||
+ | *** Contour Full Boundary of lesion with semiautomated tool; calculate volume (Vol) | ||
+ | *** Extract other measures as well (SLD from POD measureement; SLD from VOl and POD from Vol). | ||
+ | ** The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10) | ||
+ | |||
+ | ** Analyses | ||
+ | *** Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method | ||
+ | *** Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray | ||
+ | |||
+ | |||
* Related Profile: [[CT_Lung_Nodule_Volume_Quantification_Profile#Activity:_Measurement| Lung Vol Quantification - Measurement Activity]] | * Related Profile: [[CT_Lung_Nodule_Volume_Quantification_Profile#Activity:_Measurement| Lung Vol Quantification - Measurement Activity]] | ||
Revision as of 04:34, 20 April 2011
Current Goals & Status:
- Question: What is the minimum detectable level of change in patient datasets under a “No Change” condition?
- AIMS: For patient datasets acquired over a very short time interval (“no change” condition”) investigate variance in measuring change in volume, diameter and bi-directional diameters of lesions
- Investigate inter-observer variability in each task
- Investigate Intra-observer variability in each task
- Methods - Materials
- Image Data from MSK Coffee Break Experiment
- 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes
- Thin slice (1.25 mm thick) image data
- Selected one lesion per patient
- no outcome data
- Publicly Available on NCIA
- Methods - Materials
- Methods - Readings
- 5 readers
- Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability
- Methods - Measurements
- Measure Single Longest Diameter, manually (SLD)
- Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD)
- Contour Full Boundary of lesion with semiautomated tool; calculate volume (Vol)
- Extract other measures as well (SLD from POD measureement; SLD from VOl and POD from Vol).
- The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10)
- Methods - Readings
- Analyses
- Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method
- Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray
- Analyses
- Related Profile: Lung Vol Quantification - Measurement Activity
- Proposed Group 1B Questions & Datases (2009-02-10) -- Feedback Welcome -- Dr. McNitt-Gray
- ACRIN 6678 Quality Control Parameters for CT Scan Tumor Volumetric Measurements
- Conference Paper on Reproducibility and Accuracy of Uni- and Bi-Dimensional Tumor Measurements from MRI and CT Volumes, which looks at RECIST, WHO and Volume measurements.