Ultrasound SWS Biomarker Ctte

Co-chairs: Brian Garra, MD; Andrzej (Andy) Milkowski, MS

RSNA Staff Support: Julie Lisiecki

• Roster

Project Snapshot - Shear Wave Speed (SWS)

An Ultrasound Quantitative Biomarker Planning Meeting was held on Thursday, March 29, 2012 at the 2012 American Institute of Ultrasound in Medicine (AIUM) Annual Convention, in Phoenix, AZ. T he purpose of this meeting was to plan an effort by the biomedical ultrasound community to create and support implementation of a QIBA Profile for a quantitative biomarker in ultrasound imaging. Shear Wave Speed was selected as the qualifying biomarker at this meeting.

Public Comment for Version 1.0 of the Profile, QIBA US Measurement of Shear Wave Speed for Estimation of Liver Fibrosis, closed December 18, 2019.

Profile Development

Status - Integrating Public Comments received

See Profiles page for copy of the Profile: http://qibawiki.rsna.org/index.php/Profiles

Working Documents Archive

SWS Task Forces

• Combined: System Dependencies & Phantom Development Subcommittees
• Clinical Applications and Biological Targets Subcommittee
• Phantom Development Subcommittee
• System Dependencies Subcommittee
• SWS Reporting and Results Transmission Subcommittee (no charge yet provided)

Recent US-SWS Meetings

Approved call summaries:

• June 5, 2020
• February 7, 2020

US SWS Call Summaries Archive

Conferences

• 2020 Imaging-Related Conferences with links

Tools

• QIBA Mendeley Group -> Literature Database - | QIBA Mendeley Group

Literature for this the QIBA SWS Biomarker Committee has been compiled using Mendeley, and is called 'QIBA SWS'. This is a public group that anyone can join. If you would like a specific invitation to join, please email Dr. Palmeri.

• QIBA Elastic CIRS Phantom Simulation Data -> - [ https://github.com/RSNA-QIBA-US-SWS/QIBA-DigitalPhantoms ] - New data has been uploaded to the QIDW { https://qidw.rsna.org/ }

• QIBA Finite Element Tool Repository Online & Elastic / VE Simulation Data - [ https://github.com/orgs/RSNA-QIBA-US-SWS/dashboard ]

• Web browsers recommended: Firefox or Google Chrome

US Phantoms

• Exploratory QIBA Elastic and Viscoelastic homogeneous SWS calibration liver phantoms, CIRS model 039 and prototype.
• Exploratory Volume Flow Doppler Phantom with nonparabolic flow - Sun Nuclear prototype.
• Research flow phantom for contrast ultrasound testing, M. Averkiou, Univ. of Wash.

Phantom Simulation Data -> http://www.rsna.org/qidw/ https://github.com/RSNA-QIBA-US-SWS/QIBA-DigitalPhantoms

QIBA Finite Element Tool Repository Online & Elastic / Viscoelastic Simulation Data - [1]

Digital Phantoms

See ultrasound digital phantoms:

• Permanent source code for digital phantoms: https://github.com/RSNA-QIBA-US-SWS/QIBA-DigitalPhantoms(https://zenodo.org/badge/latestdoi/31222567)

• Permanent digital phantom data: https://doi.org/10.7924/r4sj1f98c (this is associated with the code above)

Software

See reference imaging system software:

• Verasonics scanner sequences and processing code: https://github.com/RSNA-QIBA-US-SWS/VerasonicsPhantomSequences

• Test Verasonics data for post-processing output: https://doi.org/10.7924/r4df6q75s

Reference Materials

Article citations:

• Sebastiani G, Alberti A. How far is noninvasive assessment of liver fibrosis from replacing liver biopsy in Hepatitis C? Journal of Viral Hepatitis,2012, 19 (Suppl. 1), 18–32. PubMed citation

Funded-Project Reports:

• FINAL REPORT-Dr. Samir - QIBA Round 3 Project (2013-2014)- posted on 3/31/2015 for Dr. Samir (Massachusetts General Hospital / Harvard )

Presentations and Reports:

• 2016 ITEC: RSNA-QIBA SWS Profile – What the Clinical Workflow Would look like and a Review of Biological Confounders Manish Dhyani, MD
• 2016 ITEC: The RSNA-QIBA SWS Profile: Current Status,Methods in Generating the Profile and a Discussion of Currently Open and Closed Issues Manish Dhyani, MD
• 2016 ITEC: QIBA SWS Profile Effects: Clinical, Research, Regulatory Brian Garra, MD
• 2016 ITEC: RSNA-QIBA Comparison of Shear Wave Speed Estimation in Viscoelastic Phantoms Tim Hall, PhD
• 2016 ITEC: Overview of QIBA Ultrasound Activity Tim Hall, PhD
• 2015 IEEE International Ultrasonics Symposium Poster: RSNA /QIBA Ultrasound Shear Wave Speed Phase II Phantom Study in Viscoelastic Media
• CIRS E2250 Phantom Measurements- presented on 7/11/2014 by Dr. Mark Palmeri (Duke University)
• Comparison of Viscoelastic Properties of CIRS Phantoms and the Human Liver - presented on 3/21/2014 by Dr. Ned Rouze (Duke University)
• Viscous Phantom Study update presented on 2/21/2014 by Dr. Hua Xie (Philips)
• presented 1/10/2014 by Dr. Nightingale: Preliminary Results –CIRS VE phantom analysis
• 2013 IEEE/UFFC Joint Symposium paper proceedings: RSNA/QIBA: Shear Wave Speed as a Biomarker for Liver Fibrosis Staging
• 2013 IEEE/UFFC Joint Symposium: RSNA/QIBA US SWS Technical Committee Poster: Shear Wave Speed as a Biomarker for Liver Fibrosis Staging
• 2012 QIBA Annual Meeting Presentation: QIBA US SHEAR WAVE SPEED Clinical Applications Committee Report
• 2012 QIBA Annual Meeting Presentation: US Modality Committee Report
• 2012 AIUM Presentation:QIBA-Blood Flow Measurement in the Hemodialysis Patient M.L. Robbin, MD
• 2012 AIUM Presentation: Novel Pushes Make Complex Shear Waves for Elasticity Imaging J. Greenleaf, PhD
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Agenda
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Sullivan Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Carson Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Cosgrove Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Garra Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Hall Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Hoyt Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Nelson Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Rognin Presentation
• QIBA Ultrasound Biomarkers Meeting, 03.29.2012-Dr. Rubin Presentation

QIBA Funded Projects

Round 3

• Project (D) Phase 2 Phantom Study with Inelastic, SWS-Dispersive Media (University of Wisconsin - Madison)

• Project (I) A Pilot Study of the Effect of Steatosis and Inflammation on Shear Wave Speed for the Estimation of Liver Fibrosis Stage in Patients with Diffuse Liver Disease (Massachusetts General Hospital)

• Project (K) Numerical Simulation of Shear Wave Speed Measurements in the Liver (Duke University)

Round 4

• Project (W) Beyond Confounders-Addressing Sources of Measurement Variability and Error in Shear Wave Elastography (Massachusetts General Hospital)

• Project (Z) Development and Validation of Simulations and Phantoms Mimicking the Viscoelastic Properties of Human Liver (Duke University)

Round 5

• Project (F) Analysis of Sources of US SWS Measurement Inter-System Variability (Duke University)