SPECT Biomarker Ctte

Project Snapshot

The SPECT Biomarker Committee seeks to develop a quantitative imaging profile for SPECT imaging.

Under consideration:

• quantifying a small structure (like the basal ganglion in the DaTscan, thyroid)
• quantifying organs, like the liver, for dosimetry as potential use cases

Established Task Forces Currently Working Toward a first Profile with title as follows below:

Quantifying Dopamine Transporters with 123-Iodine labeled Ioflupane in Neurodegenerative Disease

• Image Acquisition and Image Processing for DaTscan – Dr. Dewaraja
• Quantitative / Image Analysis – Drs. Miyaoka and Seibyl
• Phantoms / DRO Group – Drs. Dickson and Zimmerman
• Clinical / Literature Review – Dr. Seibyl

Meetings/Call Summaries

• SPECT Call Summaries

Literature Review (Profile 1.0)

• QIBA Literature Review Slides for Profile 1.0 - Dr. Seibyl March 22, 2016

• QIBA Literature Review for Profile 1.0 (Word document)- Dr. Seibyl March 22, 2016

Profile Development

• QIBA DRAFT Profile with tracked changes for recent additions - {Dr. Mozley} March 21, 2016

• QIBA DRAFT Profile with tracked changes for recent additions - {Dr. Dewaraja} March 16, 2016

• QIBA DRAFT Profile with tracked changes for recent additions - {Dr. Mozley} March 16, 2016

• QIBA DRAFT Profile - {Dr. Miyaoka} March 15, 2016

• QIBA DRAFT Profile Section 3.10 on Image Analysis - {Drs. Miyaoka and Seibyl} March 8, 2016

• QIBA DRAFT Profile: Quantifying Dopamine Transporters with 123-Iodine Labeled Ioflupane in Neurodegenerative Disease - {comments from Mr. Cella} February 17, 2016

Archived versions of the Profile

• Profile drafts

Reference Materials

• QIBA SPECT BC presentation slides - Dr. Seibyl March 8, 2016

• QIBA SPECT BC presentation slides - Dr. Frey February 2, 2016

• QIBA SPECT BC presentation slides - Dr. Buchert February 2, 2016

• QIBA SPECT BC presentation slides - Dr. Seibyl January 22, 2016

• Quantification and Image Analysis Task Force presentation slides - Dr. Miyaoka January 12, 2016

• Quantification and Image Analysis Task Force presentation slides - Dr. Seibyl January 12, 2016

• I-123 DAT SCAN - Acquisition and Reconstruction Task Force presentation slides - Dr. Dewaraja January 5, 2016

• Acquisition Processes for SPECT - Drs. Dewaraja, Frey, and Iida (notes) December 8, 2015

• System Variance Model for SPECT Ioflupane - Drs. Smith and Zeintl (Siemens) November 20, 2015

• QIBA Claim Statement Types - Dr. Obuchowski November 20, 2015

• 03.20.2015 Link to papers of the group in Umeå that are collaborating with Dr. Ljungberg:
• The PI for this is Anne Larsson, PhD: http://www.ncbi.nlm.nih.gov/pubmed/?term=dat+scan+Larsson+A