QIBA for Statisticians

QIBA Mission: Improve the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time.

QIBA develops Profile documents that standardize methods for creating a specific biomarker with predictable performance (accuracy and reproducibility).

Statisticians benefit from QIBA by:

• having good estimates of the technical performance of QIBs obtained using a given QIBA Profile
• understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
• understanding the role of technical performance characteristics in quantifying change in individual patients

Statisticians may also:

• support testing of actors’ conformance
• optimize study design in clinical trials with QIBs
• determine sample size for clinical trials using QIBs
• provide unbiased estimates of treatment effects when QIBs are endpoints

First Steps

• Review basic QIBA Concepts
• Review specific Profiles
• Review Claim Guidance and Assessment Procedure Guidance, which provide statistically-oriented background information on QIBA Profile concepts
• Contact qiba@rsna.org to get involved
• Review other Stakeholder Viewpoints