PET Amyloid Biomarker Ctte

Co-chairs: Satoshi Minoshima, MD, PhD; Anne M. Smith, PhD; Dawn C. Matthews, MS, MBA

RSNA Staff Support: Julie Lisiecki

• Roster

Project Snapshot

There is a draft Profile, and current outline of the Claim is:

• SUVr will be the measurand
• The claim will have two components

1) Cross-sectional: single subject scan

2) Longitudinal: following subject over time

Due to the complexity of having multiple PET Amyloid tracers, a subgroup, the Test-retest Group, has been formed including academics and industry representatives from all of the major PET Amyloid tracer vendors. This group will evaluate the published data on amyloid imaging precision, to determine what level of precision can be claimed in the Profile. The committee’s goal is to have a final draft Profile by December, 2015.

Collaborations: RSNA QIBA is now an affiliate of GAAIN (Global Alzheimer’s Association International Network)

PET Amyloid Meetings/Call Summaries

• May 20, 2022
• April 15, 2022
• March 11, 2022
• February 11, 2022
• January 14, 2022

PET Amyloid BC Call Summaries Archive

PET Amyloid Profile Development

Clean version of Technically Confirmed Profile for use! - also available on the Profiles {https://qibawiki.rsna.org/index.php/Profiles} page

• 18F-labeled PET Tracers Targeting Amyloid as an Imaging Biomarker-2022-06-01 clean version

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Redlined version of Technically Confirmed Profile - showing comments addressed:

• 18F-labeled PET Tracers Targeting Amyloid as an Imaging Biomarker-2022-06-01 edits redlined

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For NM CC vote - Technically Confirmed:

• 18F-labeled PET Tracers Targeting Amyloid as an Imaging Biomarker(clean version)-2022-04-14
• 18F-labeled PET Tracers Targeting Amyloid as an Imaging Biomarker(marked up version)-2022-04-14
• Profile Updates Summary-2022-04-15

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• PET F-18 for Amyloid 2018-06-20 - Consensus Profile

• 18F-labeled PET Tracers Targeting Amyloid as an Imaging Biomarker - 2018-05-02
  • QIBA Public Comments and Responses - 2018-05-02

• QIBA PET Amyloid Profile 2017-06-15 (Closed on September 15, 2017)
  • QIBA PET-Amyloid DRAFT Profile with tracked changes - 2017-06-15

• QIBA PET Amyloid Profile 2017-04-28 (BC Vote to Release for Public Comment Form: https://goo.gl/forms/0RqF8V6HlXlUNi903)

• QIBA PET Amyloid Profile Edits and Open Issues

• QIBA PET-Amyloid DRAFT Profile - CLEAN {Dr. Perlman} February 10, 2017 (PDF)

• QIBA PET-Amyloid DRAFT Profile - CLEAN {Dr. Perlman} November 11, 2016 (PDF)

• QIBA PET-Amyloid DRAFT Profile with tracked changes {Dr. Perlman} July 7, 2016 (PDF)

• QIBA PET-Amyloid DRAFT Profile with tracked changes {Dr. Perlman} April 26 - May 5, 2016

• QIBA PET-Amyloid DRAFT Profile with tracked changes {Dr. Perlman} March 28, 2016

Presentations and Reports

• 06 08 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews
• 05 11 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews
• 04 13 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews
• 03 09 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews

• 02 09 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews
• 01 12 2018 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Dr. Smith
• 01 12 2018 QIBA PET Amyloid Profile / ADNI Gap Analysis - presented by Ms. Matthews

• 10 12 2017 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Ms. Matthews

• 09 09 2016 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Dr. Smith
• 08 12 2016 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Dr. Smith
• 2015-PET-Amyloid DRO Report – Drs. Pierce, Haynor, Sunderland, and Kinahan {Part I} - Discussed on 08 12 2016 WebEx
• 2015-PET-Amyloid DRO Report – Drs. Pierce, Haynor, Sunderland, and Kinahan {Part II} - Discussed on 08 12 2016 WebEx
• Conformance Formulae - Discussed on 08 12 2016 WebEx
• QIBA Conformance Draft - Discussed on 08 12 2016 WebEx

• 03 11 2016 QIBA PET Amyloid Biomarker Committee Presentation Slides - presented by Dr. Smith

• 02 13 2015 QIBA PET Amyloid Biomarker Committee Presentation Notes - presented by Dr. Perlman

QIBA Funded Projects

Round 4

• Project (X) Amyloid Profile Continued Support with Brain Phantom Development (University of Iowa)

Round 5

• Project (A) Analyses to Support Amyloid Imaging Profile Development (ADM Diagnostics, LLC)

• Project (E) Amyloid Brain PET Test-Retest Meta-analysis (Johns Hopkins University)

• Project (I) A PET-Metabolic Tumor Volume-Digital Reference Object (PET-MTV-DRO) (University of Washington)

• Project (J) A Procedure to Facilitate Greater Standardization of PET Spatial Resolution (Johns Hopkins University)