Difference between revisions of "Lung Density Biomarker Ctte"

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==Working Documents==
==Working Documents==
*[[Media:Kemerink1996MedPhys.pdf|Density resolution in quantitative computed tomography of foam and lung - Gerrit J. Kemerink, 1996 MedPhys]]
*[[Media:Imaging_Section_of_MOP.doc|COPDGene protocol section]]
*[[Media:Kemerink1997MedPhys.pdf|The CT’s sample volume as an approximate, instrumental measure for density resolution in densitometry of the lung - Gerrit J. Kemerink, 1997 MedPhys]]
*[[Media:ECLIPSE_Protocol_ERJ.pdf|ECLIPSE protocol description]]
*[[Media:CT_protocol-v3.doc|ECLIPSE CT protocol specifics]]
*[[Media:Coxson-chairman's_summary.pdf|Coxson's chairman summary]]
*[[Media:Structural_and_Functional_Assessment_of_the_Lung_Hoffman.pdf|Hoffman et al's paper on quantitative assessment]]
*[[Media:Stoel2008PATS-volumecorrection.pdf|Stoel et al's paper on volume correction]]
*[[Media:Stoel2008PATS-longitudinalstudies.pdf|Stoel et al's paper on longitudinal studies]]

Revision as of 16:44, 5 January 2010

This Wiki is for collaborative creation of QIBA's Chronic Obstructive Pulmonary Disease (COPD) and Asthma Committee materials and ongoing activities.

Mission: Reduce and characterize bias and variance across manufacturers, versions, and sites in support of quantitative CT lung densitometry and morphology.

Initial Objectives:

  • Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.
This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.
  • Compare the sensitivity of volumetric measurements to spirometry and other accepted measures.
This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.

Project Snapshot

Profiling Activities

Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.

  • * Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is very analagous to our profiling work and addresses many similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.

Groundwork Activities

Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.

  • Phantom project

Slide Presentations

Meetings / Call Summaries

QIBA COPD/Asthma Matrices

Working Documents