Difference between revisions of "Lung Density Biomarker Ctte"

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__NOTOC__
 
__NOTOC__
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This Wiki is for collaborative creation of QIBA's Chronic Obstructive Pulmonary Disease (COPD) and Asthma Committee materials and ongoing activities.
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:Co-chairs: Charles Hatt, PhD; Miranda Kirby, PhD
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:RSNA Staff Support: Julie Lisiecki
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* [http://tinyurl.com/QIBA-CT-Lung-Density-Roster Roster]
  
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== Scope ==
  
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'''Mission''': Reduce and characterize bias and variance across manufacturers, versions, and sites in support of quantitative CT lung densitometry and morphology.   
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'''Scope''': Quantitative CT lung densitometry and morphology for COPD and related diseases.   
  
 
'''Initial Objectives''':
 
'''Initial Objectives''':
 
:* Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.   
 
:* Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.   
 
:: This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.   
 
:: This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.   
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:* Compare the sensitivity of volumetric measurements to spirometry and other accepted measures.   
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:* Compare the sensitivity of CT measurements to spirometry and other accepted measures.   
 
:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.
 
:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.
  
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==Recent Meetings/Call Summaries==
  
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*[[Media:06 23 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|June 23, 2021]]
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*[[Media:05 26 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|May 26, 2021]]
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*[[Media:04 28 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|April 28, 2021]]
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*[[Media:03 31 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|March 31, 2021]]
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*[[Media:02 24 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|February 24, 2021]]
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*[[Media:01 27 2021 QIBA CT Lung Density BC Call Summary-FINAL.pdf|January 27, 2021]]
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==Project Snapshot==
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'''''[[Lung Density/COPD BC Call Summaries Archive]]'''''
  
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==Profile Development==
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Status - <summarize current status>
  
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===Profiling Activities===
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A Google link for Public Comment Resolution has been created for ease of sharing updates with the group:
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Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
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https://docs.google.com/document/d/1uOzBaB_77vLSv8FKtQ59AxpfcAswtJ4t/edit#heading=h.gjdgxs
  
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* [[What Are Profiles?]]
 
  
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** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF80Y253N3o3aGY&hl=en|UPICT Protocol: CT Lung Neoadjuvant WoOp V0.2]
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* [[Media:QIBA_CT_Lung_Density_Profile_090420-clean.pdf | QIBA CT Lung Density Profile_09.04.2020, clean version]] (Contains Conformance Checklist, Appendix B)
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* [[Media:QIBA_CT_Lung_Density_Profile_090420-marked.pdf | QIBA CT Lung Density Profile_09.04.2020, with markup]] (Contains Conformance Checklist, Appendix B)
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* [[Media:AAPM Comments QIBA CT Lung Densitometry final-SBF031620.pdf | AAPM Comments for CT Lung Density Profile]]
  
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* [[Media:QIBA_CT_Lung_Density_Profile_090319-clean.pdf | QIBA CT Lung Density Profile_09.03.2019]] (Contains Conformance Checklist, Appendix B)
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* [[Media:checklist.pdf | QIBA CT Lung Density Profile Checklist, 09.03.2019]] (separate Conformance Checklist for ease of reference)
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:*[[Media:QIBA CT Lung Density Protocols-Appendix E.xlsx|Appendix E:CT Lung Density Protocols 2019-06-26]]
  
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* * [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is very analagous to our profiling work and addresses many similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
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* [[Media:QIBA_CT_Lung_Density_Profile_062619-appendix-resolved.pdf | QIBA CT Lung Density Profile_06.26.2019]] (Distributed August 21, 2019)
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* [[Media:QIBA_CT_Lung_Density_Profile_062619.docx | QIBA CT Lung Density Profile_06.26.2019]] (for BC and CC votes to release)
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* [[Media:QIBA_CT_Lung_Density_Profile_042519.docx | QIBA CT Lung Density Profile_04.25.2019]] (for internal BC review)
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* [[Media:QIBA_CT_Lung_Density_Protocols_Appendix_D_042519.xlsx | QIBA CT Lung Density Protocols, Appendix D_04.25.2019]] (for internal BC review)
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* [[Media:QIBA_CT_Lung_Density_Profile_022519.docx | QIBA CT Lung Density Profile_02.25.2019]] (for internal BC review)
  
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* [[Media:QIBA_CT_Lung_Density_Profile_083017-Clean.docx | QIBA CT Lung Density Profile_08.30.2017]] (for internal BC review)
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* [[Media:QIBA_AirwayProfile.doc| QIBA Airway Profile 9/28/11 - (draft per Dr. Sean Fain)]]
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* [[Media:Profile_VerIowa_LungDensity_090611_BS.SF.doc|Lung Density QIBA Profile 9/6/11 v0.4 - (Iowa Version with comments)]]
  
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===Groundwork Activities===
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'''''[[Archive - Lung Density]]'''''
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==Protocol Development Activities==
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*[http://upictwiki.ctsa-imaging.org/index.php?title=UPICT_Template UPICT Template]
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 +
 
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==Groundwork Activities==
 
Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
 
Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
  
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==Slide Presentations==
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==Working Documents==
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*[[Media:COPDDensityMatrix-V3.xls|COPD Density Matrix V3]]
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*[[Media:Mr ODonnell QIBA Process Roadmap 20090629.ppt.pdf|Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629]]
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*[[Media:COPDMorphologyMatrix-V1.xls|COPD Morphology Matrix V1]]
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==Meetings / Call Summaries==
 
  
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*[[COPD Group Call Summaries]]
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==Reference Documents==
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* [[Media:Quantitative Imaging in Lung Disorders Refresher Course Outline.doc| Quantitative Imaging in Lung Disorders Refresher Course Outline (Refresher Course at RSNA 2011:  November 30th)]]
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*[[Media:06-21-2011GammexBoxFullPath.ppt|06-21-2011GammexBoxFullPath.ppt]] ''posted 6.23.2011''
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*[[Media:06-08-2011COPDGeneModel2-GammexBox.ppt|06-08-2011 COPDGeneModel2-GammexBox.ppt]] ''posted 6.8.2011''
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*[[Media:Madani - multi-slice cut off-20100421.pdf|Pulmonary Emphysema: Objective Quantification at Multi–Detector Row CT—Comparison with Macroscopic and Microscopic Morphometry]] Madani et al, Radiology: Volume 238: Number 3-March 2006
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*[[Media:Madani - Dose CT-3-20100421.pdf|Pulmonary Emphysema: Radiation Dose and Section Thickness at Multidetector CT Quantification—Comparison with Macroscopic and Microscopic Morphometry]] Madani et al, Radiology: Volume 243: Number 1-April 2007
  
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*[[Media:Imaging_Section_of_MOP.doc|COPDGene protocol section]]
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*[[Media:ECLIPSE-Protocol-ERJ.pdf|ECLIPSE protocol description]]
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*[[Media:CT_protocol-v3.doc|ECLIPSE CT protocol specifics]]
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*[[Media:Coxson-chairman's_summary.pdf|Coxson's chairman summary]]
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*[[Media:Structural_and_Functional_Assessment_of_the_Lung_Hoffman.pdf|Hoffman et al's paper on quantitative assessment]]
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*[[Media:Stoel2008PATS-volumecorrection.pdf|Stoel et al's paper on volume correction]]
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*[[Media:Stoel2008PATS-longitudinalstudies.pdf|Stoel et al's paper on longitudinal studies]]
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*[[Media:FDA-COPDGuidance-20100201.pdf|FDA Guidance for Industry - Chronic Obstructive Pulmonary Disease: Developing Drugs for Treatment]]
  
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==QIBA COPD/Asthma Matrices==
 
  
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*[[Media:COPDDensityMatrix-V3.xls|COPD Density Matrix V3]]
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==QIBA Funded Projects==
  
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*[[Media:COPDMorphologyMatrix-V1.xls|COPD Morphology Matrix V1]]
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====Round 2====
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*[[University of Wisconsin]]
  
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====Round 4====
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*[[Media:Low CT Dose Lung Protocols for Repeatable Quantitative Measures in Multi-Center Studies.pdf | Project (Y) Low CT Dose Lung Protocols for Repeatable Quantitative Measures in Multi-Center Studies (University of Wisconsin, Madison)]]
  
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==Working Documents==
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====Round 5====
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*[[Media:Investigation of Methods of Volume Correction for Lung Density CT.pdf | Project (L) Investigation of Methods of Volume Correction for Lung Density CT (University of Wisconsin, Madison)]]
  
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*[[Media:Kemerink1996MedPhys.pdf|Density resolution in quantitative computed tomography of foam and lung - Gerrit J. Kemerink, 1996 MedPhys]]
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====Round 6====
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*[[Media:Kemerink1997MedPhys.pdf|The CT’s sample volume as an approximate, instrumental measure for density resolution in densitometry of the lung - Gerrit J. Kemerink, 1997 MedPhys]]
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*[[Media:Translating Phantom Harmonization to Clinical Practice.pdf | Project (U) CT Lung Density Biomarker-Translating Phantom Harmonization to Clinical Practice (National Jewish Health)]]

Revision as of 19:59, 7 June 2021

Co-chairs: Charles Hatt, PhD; Miranda Kirby, PhD
RSNA Staff Support: Julie Lisiecki

Scope

Scope: Quantitative CT lung densitometry and morphology for COPD and related diseases.

Initial Objectives:

  • Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.
This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.
  • Compare the sensitivity of CT measurements to spirometry and other accepted measures.
This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.

Recent Meetings/Call Summaries


Lung Density/COPD BC Call Summaries Archive

Profile Development

Status - <summarize current status>

A Google link for Public Comment Resolution has been created for ease of sharing updates with the group: https://docs.google.com/document/d/1uOzBaB_77vLSv8FKtQ59AxpfcAswtJ4t/edit#heading=h.gjdgxs


Archive - Lung Density

Protocol Development Activities


Groundwork Activities

Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.

  • Phantom project


Working Documents


Reference Documents


QIBA Funded Projects

Round 2

Round 4

Round 5

Round 6

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