Lung Density Biomarker Ctte

Co-chairs: Sean Fain, PhD; Matthew Fuld, PhD; David Lynch, MD

Secretary: Julie Lisiecki

• Roster

Scope

Scope: Quantitative CT lung densitometry and morphology for COPD and related diseases.

Initial Objectives:

• Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.

This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.

• Compare the sensitivity of CT measurements to spirometry and other accepted measures.

This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.

Recent Meetings/Call Summaries

• 10.11.2017 QIBA Lung Density Biomarker Committee Call Summary
• 09.13.2017 QIBA Lung Density Biomarker Committee Call Summary
• 08.30.2017 QIBA Lung Density Biomarker Committee Call Summary
• 08.16.2017 QIBA Lung Density Biomarker Committee Call Summary

Lung Density/COPD BC Call Summaries Archive

Profile Development

Status - <summarize current status>

• QIBA QIBA CT Lung Density Profile_08.30.2017 (for internal BC review)
• QIBA Airway Profile 9/28/11 - (draft per Dr. Sean Fain)
• Lung Density QIBA Profile 9/6/11 v0.4 - (Iowa Version with comments)

Archive - Lung Density

Protocol Development Activities

• UPICT Template

Groundwork Activities

Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.

• Phantom project

Working Documents

• COPD Density Matrix V3

• COPD Morphology Matrix V1

Reference Documents

• Quantitative Imaging in Lung Disorders Refresher Course Outline (Refresher Course at RSNA 2011: November 30th)

• 06-21-2011GammexBoxFullPath.ppt posted 6.23.2011

• 06-08-2011 COPDGeneModel2-GammexBox.ppt posted 6.8.2011

• Pulmonary Emphysema: Objective Quantification at Multi–Detector Row CT—Comparison with Macroscopic and Microscopic Morphometry Madani et al, Radiology: Volume 238: Number 3-March 2006

• Pulmonary Emphysema: Radiation Dose and Section Thickness at Multidetector CT Quantification—Comparison with Macroscopic and Microscopic Morphometry Madani et al, Radiology: Volume 243: Number 1-April 2007

• COPDGene protocol section
• ECLIPSE protocol description
• ECLIPSE CT protocol specifics
• Coxson's chairman summary
• Hoffman et al's paper on quantitative assessment
• Stoel et al's paper on volume correction
• Stoel et al's paper on longitudinal studies
• FDA Guidance for Industry - Chronic Obstructive Pulmonary Disease: Developing Drugs for Treatment

Round 2 of QIBA Funded Projects

• University of Wisconsin