Difference between revisions of "Lung Density Biomarker Ctte"

Revision as of 03:23, 22 November 2016

Co-chairs: Sean Fain, PhD; Matthew Fuld, PhD; David Lynch, MD

Secretary: Julie Lisiecki

Scope: Quantitative CT lung densitometry and morphology for COPD and related diseases.

Initial Objectives:

Characterize the precision and accuracy of phenotyping and progression measurements in emphysema and asthma.

This is an essential effort to classify phenotype and assess longitudinal changes as medically meaningful surrogates for health status.

Compare the sensitivity of CT measurements to spirometry and other accepted measures.

This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with quantitative imaging techniques than with currently accepted methods.

Meetings

Profiling Activities

Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629

Claim Language/Detail

Protocol Development Activities

UPICT Template

Groundwork Activities

Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.

Phantom project

Working Documents

COPD Density Matrix V3

COPD Morphology Matrix V1

Reference Documents

Quantitative Imaging in Lung Disorders Refresher Course Outline (Refresher Course at RSNA 2011: November 30th)

06-21-2011GammexBoxFullPath.ppt posted 6.23.2011

06-08-2011 COPDGeneModel2-GammexBox.ppt posted 6.8.2011

Pulmonary Emphysema: Objective Quantification at Multi–Detector Row CT—Comparison with Macroscopic and Microscopic Morphometry Madani et al, Radiology: Volume 238: Number 3-March 2006

Pulmonary Emphysema: Radiation Dose and Section Thickness at Multidetector CT Quantification—Comparison with Macroscopic and Microscopic Morphometry Madani et al, Radiology: Volume 243: Number 1-April 2007

Round 2 of QIBA Funded Projects

University of Wisconsin

@@ Line 4: / Line 4: @@
 :Roster: [[Media:QIBA CT-Lung Density Roster.pdf|(Roster)]]
-This Wiki is for collaborative creation of QIBA's Chronic Obstructive Pulmonary Disease (COPD) and Asthma Committee materials and ongoing activities.
+'''Scope''': Quantitative CT lung densitometry and morphology for COPD and related diseases.
-'''Please note''':<font color=red> As of July 2014, the group has been renamed as the ''QIBA Lung Density Biomarker Committee''.</font>
-'''Mission''': Reduce and characterize bias and variance across manufacturers, versions, and sites in support of quantitative CT lung densitometry and morphology.
 '''Initial Objectives''':