Difference between revisions of "FDG-PET Biomarker Ctte"
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Revision as of 21:31, 29 October 2009
FDG-PET/CT Technical Committee Page
Mission; Foster adoption of ...
- pragmatic and cost effective standards for
- accurate and reproducible
- longitudinal
- quantitation of
- biologic parameters
- with clinical relevance
- and known sigma
SubCommittees
- Covariates Rationale
- Standardized Uptake Value (SUV)
- Quality Control Metrics
- ROI Definition
- Software Version Tracking
Profiling Activities
Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
Reference Materials
The Netherlands Standardization Protocol for Quantitative FDG-PET in Multi-center Trials (English translation of Version 1)
Please keep the following in mind:
The development of this protocol was started about 4 years ago (2005) and approved more than 1 year ago in The Netherlands (NL). However, with gained insight, changes are scheduled to be incorporated in the next version by 2010. The following changes will be made (consider them being applied already or underway):
- Use of oral contrast is now excluded but will be allowed in the next version
- We are currently working on standards for CT as well, including GL for doing CT-QC (in cooperation with the radiologists/radiology societies in NL)
- There will be an upper limit for dosage
- We are working on traceable/calibrated and mutually linked sources for both PET and the dose calibrator and these will be used for absolute (rather than cross-) calibration (but in addition to the cross-calibration using FDG).
- Reconstruction settings given in the protocol are indicative and are likely not applicable for future scanners and software upgrades. Therefore reconstruction parameters should be set such that they provide results that meet the specifications given for the multi-center QC experiments. Same settings should then be applied to patient studies (see also comments under "execptions/special features” and comments made in the paper by Boellaard et al. EJNMMI 2008).
- Various other minor edits/typos/changes
The protocol is not a step-by-step description of the logistics for doing a PET/CT study. However, it has been set up in a somewhat chronological order and may thus be used to populate (copy-paste) such a step-by-step description. Additional work required ... FDG-PET/CT Technical Committee input is highly appreciated.
Submitted by Ronald Boellaard, PhD
Submitted by Richard L. Wahl, MD and Martin A. Lodge, PhD
Submitted by Eric S. Perlman, MD
Slide Presentations
- QIBA Informational Meeting (Dec 1st at RSNA 2008) - Slide Content Review
- QIBA Working Meeting (Dec 4th at RSNA 2008) - FDG-PET/CT Breakout Session Slide Deck
- Fused Images
- Media:FDG-PET11-29.ppt
- QIBA FDG-PET/CT Mission Statement - 2009.03.10
- QIBA Profiling Process-03.31.2009 (Andrew Buckler, MS)
- FDG-PET/CT Technical Committee summary 2009.05.20 Richard Frank