CT Volumetry Biomarker Ctte

Project Snapshot

• "Why QIBA?" - Specifics associated with CT device and software manufacturers.
• Project plan .jpg version as of 11-8-10

See the Datasets page of the QIBA Resource Catalog

Meetings / Call Summaries

• Call Summaries

Profile Development

• VIA Profile v1.5 Word version as preparatory for drafting v2.0, 01-09-2011
• VIA Protocol v1.4 Word version as placed into field test known as v1.0, 9-11-2010
• UPICT Template for CT Lung Neoadjuvant WoOp Protocol V0.2 Google doc version of early stage disease, 01-04-2010

Working Documents

Active work:

• VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
• VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
• VolCT - Group 3A - Characterize variability due to algorithm using phantoms
• VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints

Completed work:

• UPICT Template for CT Lung Nodule Protocol Google doc version of v1.4 WIP
• Quantification in Imaging-Dr Dirk Colditz August 23, 2010
• Work Breakdown for Volumetric CT 07.12.10
• VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
• 2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors - long version
• VIA Profile v1.1 Word version 09-03-2009
• Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites Last updated 6/2009
• Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting Last updated 6/2009
• Validation Roadmap - P. David Mozley, MD
• Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629
• VolCT - Group 2 - Set Standards for using Volumetric Imaging in Clinical Trials
• Profile Strategy for Vol CT
• Initial Target Selection - describing the early prioritization discussions and settling on Lung Tumor Volumes
• Sources of Variability - Andrew Buckler

Reference Materials

• Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
• Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
• Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
• Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology
• What Are Profiles?