CT Volumetry Biomarker Ctte

Project Snapshot

• "Why QIBA?" - Specifics associated with CT device and software manufacturers.
• Project plan .jpg version as of 11-8-10

See the Datasets page of the QIBA Resource Catalog

Meetings / Call Summaries

• Call Agenda Topics
• Call Summaries

Profile Development

Drafting:

• Advanced disease:
  • Advanced Disease Profile v1.7 post call Word version as preparatory for drafting "version two" applicable to late stage disease in multiple organ systems
  • Advanced Disease Protocol v1.7 UPICT Protocol
• Small nodule:
  • Small Nodule Profile v0.7 Profile applicable to small pulmonary nodules
  • Small Nodule Profile v0.6 03/12/2011

Field Test:

• VIA Protocol v1.4.1 Word version currently under field test as "version one" applicable to late stage disease, 09-11-2010

Working Documents

Active:

• VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
• VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
• VolCT - Group 3A - Characterize variability due to algorithm using phantoms
• VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints

No longer active:

• VIA Profile v1.6 02/28/2011
• VIA Profile v1.5 01/09/2011
• VIA Protocol v1.4 Word version known as field test v1.0, 09-09-2010
• UPICT Template for CT Lung Nodule Protocol Google doc version of v1.4 WIP
• Quantification in Imaging-Dr Dirk Colditz August 23, 2010
• Work Breakdown for Volumetric CT 07.12.10
• VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
• 2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors - long version
• VIA Profile v1.1 Word version 09-03-2009
• Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites Last updated 6/2009
• Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting Last updated 6/2009
• Validation Roadmap - P. David Mozley, MD
• Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629
• VolCT - Group 2 - Set Standards for using Volumetric Imaging in Clinical Trials
• Profile Strategy for Vol CT
• Initial Target Selection - describing the early prioritization discussions and settling on Lung Tumor Volumes
• Sources of Variability - Andrew Buckler

Reference Materials

• Dr Petrick's 2011 SPIE Presentation Materials
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper

• Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology

• Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
• Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
• Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

Round 1 of QIBA Funded Projects

• TBN
• Duke University
• Columbia University Medical Center
• University of Colorado Denver, Department of Radiology
• David Geffen School of Medicine at UCLA, Department of Radiology