CT Volumetry Biomarker Ctte

Co-chairs: Gregory Goldmacher, MD, PhD, MBA; Jenifer Siegelman, MD, MPH; Ehsan Samei, PhD

Secretary: Julie Lisiecki

Roster: (Roster)

Meetings

• Upcoming Calls/Meetings: <link to calendar of meetings>
• Call Summaries

• Lung Nodule Assessment in CT Screening Call Summary Archive

Profile Development

Advanced Disease/Tumor Volume Change Profile

Profile Feasibility Testing

• Invitation to Participate

• QIBA Profile: CT Tumor Volume Change Profile 2016.10.18

• Archived Versions of QIBA draft CT Volumetry Profile-related documents.
• Considerations for Future Editions of CTV-AD

Lung Nodule Assessment in CT Screening

Status - Now Resolving Public Comment

• QIBA Profile: CT Volumetry: Lung Nodule Volume Assessment and Monitoring in Lung Cancer Screening, 02.05.2014 '5February2014'

• Archive for Lung Nodule Assessment in CT Screening Draft Profiles

Groundwork Projects

These projects investigate (and resolve) scientific questions underlying QIBA Profile work.

• VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
• VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
• VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
• VolCT - Group 3A - Characterize variability due to algorithms (using phantoms / clinical data)
• VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints
• VolCT - Colorado Group - Quantifying variability in measurement of pulmonary nodule

• NIBIB-2 Proposal for CT Volumetry16-APR-2012

Reference Materials

2012

• Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
  • ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.
• "Why QIBA?" - Specifics associated with CT device and software manufacturers.

2011

• Dr Petrick's 2011 SPIE Presentation Materials
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper
• Compliance Documents: QIBA Approach to Compliance-- Andrew J. Buckler, MS, Program Director, QIBA 08.15.11

2010

• Quantification in Imaging-Dr Dirk Colditz August 23, 2010
• Project plan .jpg version as of 11-8-10

Reference Articles

• Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
• Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
• Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
• Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

• Archive - Initial Target Selection and Roadmap

Round 1 of QIBA Funded Projects

• Duke University
• Columbia University Medical Center
• University of Colorado Denver, Department of Radiology
• David Geffen School of Medicine at UCLA, Department of Radiology
• CoreLab Partners, Inc.

Round 2 of QIBA Funded Projects

• CoreLab Partners, Inc., Round-2
• David Geffen School of Medicine at UCLA, Department of Radiology,Round-2