Difference between revisions of "CT Volumetry Biomarker Ctte"

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__NOTOC__
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This Wiki is for collaborative creation of QIBA's Volumetric CT Technical Committee materials and ongoing activities.
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:Co-chairs: Rudresh Jarecha, MBBS, DNB, DMRE; Ehsan Samei, PhD and TBD
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:RSNA Staff Support: Julie Lisiecki
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* [http://tinyurl.com/QIBA-CT-Vol-Roster Roster]
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* [https://docs.google.com/spreadsheets/d/1qbBHaJNTAqHnAcmCTHsNfDph7hMyJ3NoUjYSdilVw8w/edit#gid=267283460 Attendance & Voting Privileges]
  
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==Meetings==
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* Tcons are held periodically. Contact RSNA Staff for details.
  
'''Mission''': Investigate the technical feasibility and medical value of quantifying longitudinal changes in volume with CT. 
 
  
'''Initial Objectives''':
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'''Recent Call Summaries:'''
:* Characterize the precision and accuracy of volumetric tumor measurements.
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*[[Media:08 24 2021 QIBA CT Volumetry Profile TF Call-FINAL.pdf|08.24.2021 QIBA CT Volumetry Profile TF Call Summary]]
:: This will be an essential prelude for understanding the threshold that will be needed to classify longitudinal changes in tumor volume as medically meaningful surrogates for changes in health status.
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*[[Media:07 26 2021 QIBA CT Volumetry Profile TF Call-FINAL.pdf|07.26.2021 QIBA CT Volumetry Profile TF Call Summary]]
:* Compare the sensitivity of volumetric measurements to RECIST/ World Health Organization (WHO) (conventional & modified) outcome measures.
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*[[Media:06 17 2021 QIBA CT Volumetry BC Call-FINAL.pdf|06.17.2021 QIBA CT Volumetry BC Call Summary]]
:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with volumetric techniques than with uni- or bi-dimensional line-lengths placed on a single slice.
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*[[Media:05 06 2021 QIBA CT Volumetry BC Call-FINAL.pdf|05.06.2021 QIBA CT Volumetry BC Call Summary]]
  
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*[[Media:07 23 2020 QIBA CT Volumetry BC Call-FINAL.pdf|07.23.2020 QIBA CT Volumetry BC Call Summary]]
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*[[Media:06 02 2020 QIBA CT Volumetry TF Call-FINAL.pdf|06.02.2020 QIBA CT Volumetry TF Call Summary]]
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*[[Media:04 30 2020 QIBA CT Volumetry Tf Call-FINAL.pdf|04.30.2020 QIBA CT Volumetry TF Call Summary]]
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*[[Media:03 12 2020 QIBA CT Volumetry BC Call-FINAL.pdf|03.12.2020 QIBA CT Volumetry Call Summary]]
  
==Project Snapshot==
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'''''[[CT Volumetry BC Call Summaries Archive]]'''''
  
'''[[Quantitative Response Metrics for Lung Cancer]]''' was selected as a useful concrete focus to get started.
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==Profile Development==
  
===Profiling Activities===
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===Advanced Disease/Tumor Volume Change Profile===
Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
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* [[What Are Profiles?]]
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'''Status - Technical Confirmation in Ballot'''
  
* [[CT Lung Nodule Volume Quantification Profile]]
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*[[Media:QIBA_CTVol_TumorVolumeChangeProfile_DraftTechConfirmed-20180511-changetracked.docx | CT Tumor Volume Change Profile - Change tracked]] ''BALLOT DRAFT 2018.05.11''
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** This document shows all changes between the published Consensus Profile and the Ballot for Technically Confirmed.
  
  
===Groundwork Activities===
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Past and Future
Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
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:* [[Archived Versions#Advanced_disease|Archived Versions]] of Profile-related documents.
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:* [[CTV-AD Considerations for Future Editions|Considerations for Future Editions of CTV-AD]]
  
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==Groundwork Projects==
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These projects investigate (and resolve) scientific questions underlying QIBA Profile work.
 
* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
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* [[VolCT - Group 3A]] - Characterize variability due to algorithms (using phantoms / clinical data)
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* [[VolCT - Group 3B]] - Characterize clinical utility/efficacy with respect to clinical endpoints
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* [[VolCT - Colorado Group]] - Quantifying variability in measurement of pulmonary nodule
  
* [[VolCT - Group 2]] - Set Standards for using Volumetric Imaging in Clinical Trials
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*[[Media:NIBIB-2 Proposal for CT Volumetry 16APR2012.pdf|NIBIB-2 Proposal for CT Volumetry]]''16-APR-2012''
  
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==Reference Materials==
  
==Working Documents==
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'''2012'''
* [[Initial Target Selection]] - describing the early prioritization discussions and settling on Lung Tumor Volumes
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*Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
*[[Media:2008.12.16.Sources_of_Variability_-_Andrew_Buckler.xls|Sources of Variability - Andrew Buckler]]
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**[[Media:ATCC is an independent private nonprofit 7-3-12.pdf|ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.]]
*[[Media:2008.09.15.Validation_Roadmap_VOL-CT_Image_Analysis.pdf|Validation Roadmap - P. David Mozley, MD]]
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*[[Media:Why_QIBA_CT_specifics.pdf|"Why QIBA?" - Specifics associated with CT device and software manufacturers.]]
*[[Media:2008.09.13-QIBA_Process-Groundwork_and_Profiling_Kevin_ODonnell.pdf|Process Groundwork & Profiling - Kevin O'Donnell]] - See also the '''[[Groundwork and Profiling|Wiki Version]]'''
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==Slide Presentations==
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'''2011'''
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*Dr Petrick's 2011 SPIE Presentation Materials
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*[[Media:Spie2011 NP QIBA1A-Talk-v05-final-1.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk]]
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*[[Media:Spie2011 NP QIBA1A-Paper-v08-final-2.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper]]
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*Compliance Documents: [[Media:Approach to Compliance 2011 08 15.pdf|QIBA Approach to Compliance-- ''Andrew J. Buckler, MS, Program Director, QIBA 08.15.11'']]
  
==Meetings / Call Summaries==
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'''2010'''
*[[Call Summaries]]
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*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
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*[[Media: Plan as of 11-8-10.jpg|Project plan]] ''.jpg version as of 11-8-10''
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==Reference Articles==
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*Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
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* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses  similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
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*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
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*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
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*[[Archive - Initial Target Selection and Roadmap]]
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==QIBA Funded Projects==
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'''Round 1'''
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*[[Duke University]]
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*[[Columbia University Medical Center]]
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*[[University of Colorado Denver, Department of Radiology]]
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*[[David Geffen School of Medicine at UCLA, Department of Radiology]]
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*[[CoreLab Partners, Inc.]]
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'''Round 2'''
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*[[CoreLab Partners, Inc., Round-2]]
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*[[David Geffen School of Medicine at UCLA, Department of Radiology,Round-2]]
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'''Round 3'''
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*[[Media:Second 3A Statistical and Image Processing Analysis.pdf | Project (F) Second 3A Statistical and Image Processing Analysis (Elucid Bioimaging Inc.)]]
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'''Round 4'''
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*[[Media:Methodology and Reference Image Set for Volumetric Characterization and Compliance.pdf | Project (Q) Phantoms Methodology and Reference Image Set for Volumetric Characterization and Compliance (Duke University)]]
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*[[Media:Phantoms for CT Volumetry of Hepatic and Nodal Metastasis.pdf | Project (S) Phantoms for CT Volumetry of Hepatic and Nodal Metastasis (CUMC)]]
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'''Round 5'''
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*[[Media:Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization.pdf | Project (C) Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization (Duke University)]]
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'''Round 6'''
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*[[Media:Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology.pdf | Project (S) Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology (Duke University)]]

Latest revision as of 21:41, 24 August 2021

Co-chairs: Rudresh Jarecha, MBBS, DNB, DMRE; Ehsan Samei, PhD and TBD
RSNA Staff Support: Julie Lisiecki

Meetings

  • Tcons are held periodically. Contact RSNA Staff for details.


Recent Call Summaries:

CT Volumetry BC Call Summaries Archive

Profile Development

Advanced Disease/Tumor Volume Change Profile

Status - Technical Confirmation in Ballot


Past and Future

Groundwork Projects

These projects investigate (and resolve) scientific questions underlying QIBA Profile work.

  • VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
  • VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
  • VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
  • VolCT - Group 3A - Characterize variability due to algorithms (using phantoms / clinical data)
  • VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints
  • VolCT - Colorado Group - Quantifying variability in measurement of pulmonary nodule

Reference Materials

2012

2011

2010

Reference Articles

  • Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
  • Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
  • Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
  • Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

QIBA Funded Projects

Round 1

Round 2

Round 3

Round 4

Round 5

Round 6