Difference between revisions of "CT Volumetry Biomarker Ctte"

Latest revision as of 19:14, 17 January 2024

Co-chairs: Ritu Gill, MD, MPH, Rudresh Jarecha, MBBS, DNB, DMRE, and Ehsan Samei, PhD

Recent Call Summaries:

03.21.2023 QIBA CT Volumetry BC Call Summary

CT Volumetry BC Call Summaries Archive

Profile Development

Streamlined Profile (also on Profile page)

CT Tumor Volume Change for Advanced Disease (CTV-AD) 2022-07-21 Streamlined Profile

32 pages including Conformance Checklists

Status - Balloting Streamlined Profile

CT Tumor Volume Change Profile - Streamlined Draft 2022.03.03
CT Tumor Volume Change Profile - Streamlined Draft 2021.12.09

The Technically Confirmed Profile is on the Profiles page.

Stage 4 Planning

Draft Stage 4 Plan - Google Doc

Past and Future

Archived Versions of Profile-related documents.
Considerations for Future Editions of CTV-AD

Groundwork Projects

These projects investigate (and resolve) scientific questions underlying QIBA Profile work.

VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
VolCT - Group 3A - Characterize variability due to algorithms (using phantoms / clinical data)
VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints
VolCT - Colorado Group - Quantifying variability in measurement of pulmonary nodule

NIBIB-2 Proposal for CT Volumetry16-APR-2012

Reference Materials

2012

Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
- ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.
"Why QIBA?" - Specifics associated with CT device and software manufacturers.

2011

Dr Petrick's 2011 SPIE Presentation Materials
“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk
“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper
Compliance Documents: QIBA Approach to Compliance-- Andrew J. Buckler, MS, Program Director, QIBA 08.15.11

2010

Quantification in Imaging-Dr Dirk Colditz August 23, 2010
Project plan .jpg version as of 11-8-10

Reference Articles

Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

Archive - Initial Target Selection and Roadmap

QIBA Funded Projects

Round 1

Round 2

Round 3

Project (F) Second 3A Statistical and Image Processing Analysis (Elucid Bioimaging Inc.)

Round 4

Project (Q) Phantoms Methodology and Reference Image Set for Volumetric Characterization and Compliance (Duke University)

Project (S) Phantoms for CT Volumetry of Hepatic and Nodal Metastasis (CUMC)

Round 5

Project (C) Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization (Duke University)

Round 6

Project (S) Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology (Duke University)

@@ Line 1: / Line 1: @@
-__NOTOC__
+{{TOCright}}
-This Wiki is for collaborative creation of QIBA's Volumetric CT Technical Committee materials and ongoing activities.
+:Co-chairs: Ritu Gill, MD, MPH, Rudresh Jarecha, MBBS, DNB, DMRE, and Ehsan Samei, PhD
+* [http://tinyurl.com/QIBA-CT-Vol-Roster Roster]
+* [https://docs.google.com/spreadsheets/d/1qbBHaJNTAqHnAcmCTHsNfDph7hMyJ3NoUjYSdilVw8w/edit#gid=267283460 Attendance & Voting Privileges]
-'''Mission''': Investigate the technical feasibility and medical value of quantifying longitudinal changes in volume with CT.
-'''Initial Objectives''':
+'''Recent Call Summaries:'''
-:* Characterize the precision and accuracy of volumetric tumor measurements.
+*[[Media:03 21 2023 QIBA CT Volumetry BC Call-FINAL.pdf|03.21.2023 QIBA CT Volumetry BC Call Summary]]
-:: This will be an essential prelude for understanding the threshold that will be needed to classify longitudinal changes in tumor volume as medically meaningful surrogates for changes in health status.
-:* Compare the sensitivity of volumetric measurements to RECIST/ World Health Organization (WHO) (conventional & modified) outcome measures.
-:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with volumetric techniques than with uni- or bi-dimensional line-lengths placed on a single slice.
-In a graphic, therapy assessment looks like this (this slide and the two following courtesy R. Avila):'''
+'''''[[CT Volumetry BC Call Summaries Archive]]'''''
-[[Image:Therapy Assessment.jpg]]
+==Profile Development==
+'''Streamlined Profile (also on Profile page)'''
+* [[Media:QIBACTVol_TumorVolumeChange(2022)-20220721.pdf|CT Tumor Volume Change for Advanced Disease (CTV-AD) 2022-07-21 Streamlined Profile]]
+:* 32 pages including Conformance Checklists
-'''The present defacto standard applies the following methodolgy:'''
+'''Status - Balloting Streamlined Profile'''
+*[[Media:QIBA Profile Streamlining Proposal - CTVol TumorVolumeChange-20220303.docx| CT Tumor Volume Change Profile - Streamlined]] Draft 2022.03.03
+*[[Media:QIBA Profile Streamlining Proposal - CTVol TumorVolumeChange-20211209.docx| CT Tumor Volume Change Profile - Streamlined]] Draft 2021.12.09
-[[Image:RECIST Baseline.jpg]]
+The Technically Confirmed Profile is on the [[Profiles]] page.
+'''Stage 4 Planning'''
+:* [https://docs.google.com/document/d/1Wcmkzp8N_2lLL-FCykNPwgsn1BJOs7Z9A1ZyTIkuGCo/edit?usp=sharing Draft Stage 4 Plan - Google Doc]
-'''Our goals are to address bias and variance, which in turn outght to allow shorter trials and/or lower enrollments:'''
+'''Past and Future'''
+:* [[Archived Versions#Advanced_disease|Archived Versions]] of Profile-related documents.
-[[Image:We Can Do Better.jpg]]
+:* [[CTV-AD Considerations for Future Editions|Considerations for Future Editions of CTV-AD]]
-'''To accomplish this,''' we adopt the following flow which represents the structure of our effort as well as the resulting output we achieve:
-[[Image:QIBA Process for VolCT.jpg]]
-==Project Snapshot==
-'''[[Quantitative Response Metrics for Lung Cancer]]''' was selected as a useful concrete focus to get started.
-===Profiling Activities===
-Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
-* [[What Are Profiles?]]
-* [[Profile Strategy for Vol CT]]
-** [[Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites]]
-** [[Profile: CT Lung Nodule Volume Change for Primary, Hilar and Medistinal Lymph Nodes]]
-** [[Profile: CT Lung Nodule Response]]
-** [[Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting]]
-**
-** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF8zcHFkdnhqY3A&hl=en|UPICT Protocol: CT Lung Nodule V1.3]
-** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF80Y253N3o3aGY&hl=en|UPICT Protocol: CT Lung Neoadjuvant WoOp V0.2]
-* [[Profile Template]] - still evolving
-* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is very analagous to our profiling work and addresses many similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
-===Groundwork Activities===
-Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
+==Groundwork Projects==
+These projects investigate (and resolve) scientific questions underlying QIBA Profile work.
 * [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 * [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
 * [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
+* [[VolCT - Group 3A]] - Characterize variability due to algorithms (using phantoms / clinical data)
+* [[VolCT - Group 3B]] - Characterize clinical utility/efficacy with respect to clinical endpoints
+* [[VolCT - Colorado Group]] - Quantifying variability in measurement of pulmonary nodule
-* [[VolCT - Group 2]] - Set Standards for using Volumetric Imaging in Clinical Trials
+*[[Media:NIBIB-2 Proposal for CT Volumetry 16APR2012.pdf|NIBIB-2 Proposal for CT Volumetry]]''16-APR-2012''
+==Reference Materials==
-==Working Documents==
+'''2012'''
-* [[Initial Target Selection]] - describing the early prioritization discussions and settling on Lung Tumor Volumes
+*Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
-*[[Media:2008.12.16.Sources_of_Variability_-_Andrew_Buckler.xls|Sources of Variability - Andrew Buckler]]
+**[[Media:ATCC is an independent private nonprofit 7-3-12.pdf|ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.]]
-*[[Media:2008.09.15.Validation_Roadmap_VOL-CT_Image_Analysis.pdf|Validation Roadmap - P. David Mozley, MD]]
+*[[Media:Why QIBA CT specifics.pdf|"Why QIBA?" - Specifics associated with CT device and software manufacturers.]]
-*[[Media:2008.09.13-QIBA_Process-Groundwork_and_Profiling_Kevin_ODonnell.pdf|Process Groundwork & Profiling - Kevin O'Donnell]] - See also the '''[[Groundwork and Profiling|Wiki Version]]'''
-*[[Media:VolCTMatrix-Strawman-ver5-20090915.xls|Vol-CT Matrix (v5) 20090915]]
+'''2011'''
+*Dr Petrick's 2011 SPIE Presentation Materials
+*[[Media:Spie2011 NP QIBA1A-Talk-v05-final-1.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk]]
+*[[Media:Spie2011 NP QIBA1A-Paper-v08-final-2.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper]]
+*Compliance Documents: [[Media:Approach to Compliance 2011 08 15.pdf|QIBA Approach to Compliance-- ''Andrew J. Buckler, MS, Program Director, QIBA 08.15.11'']]
+'''2010'''
+*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
+*[[Media:Plan as of 11-8-10.jpg|Project plan]] ''.jpg version as of 11-8-10''
+==Reference Articles==
 *Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
+* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses  similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
+*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
+*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
-*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
+*[[Archive - Initial Target Selection and Roadmap]]
-*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
+==QIBA Funded Projects==
-==Slide Presentations==
+'''Round 1'''
+*[[Duke University]]
+*[[Columbia University Medical Center]]
+*[[University of Colorado Denver, Department of Radiology]]
+*[[David Geffen School of Medicine at UCLA, Department of Radiology]]
+*[[CoreLab Partners, Inc.]]
+'''Round 2'''
+*[[CoreLab Partners, Inc., Round-2]]
+*[[David Geffen School of Medicine at UCLA, Department of Radiology,Round-2]]
-*[[Media:Mr ODonnell QIBA Process Roadmap 20090629.ppt.pdf|Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629]]
+'''Round 3'''
+*[[Media:Second 3A Statistical and Image Processing Analysis.pdf| Project (F) Second 3A Statistical and Image Processing Analysis (Elucid Bioimaging Inc.)]]
+'''Round 4'''
+*[[Media:Methodology and Reference Image Set for Volumetric Characterization and Compliance.pdf| Project (Q) Phantoms Methodology and Reference Image Set for Volumetric Characterization and Compliance (Duke University)]]
-==MSK Coffee Break Image Sets==
+*[[Media:Phantoms for CT Volumetry of Hepatic and Nodal Metastasis.pdf| Project (S) Phantoms for CT Volumetry of Hepatic and Nodal Metastasis (CUMC)]]
-'''[[:Category:Datasets| See the Datasets page]]''' of the [[Catalog|QIBA Resource Catalog]]
+'''Round 5'''
+*[[Media:Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization.pdf| Project (C) Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization (Duke University)]]
-==Meetings / Call Summaries==
+'''Round 6'''
-*[[Call Summaries]]
+*[[Media:Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology.pdf| Project (S) Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology (Duke University)]]