Difference between revisions of "CT Volumetry Biomarker Ctte"

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__NOTOC__
 
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This Wiki is for collaborative creation of QIBA's Volumetric CT Technical Committee materials and ongoing activities.
 
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'''Mission''': Investigate the technical feasibility and medical value of quantifying longitudinal changes in volume with CT. 
 
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'''Initial Objectives''':
 
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:* Characterize the precision and accuracy of volumetric tumor measurements. 
 
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:: This will be an essential prelude for understanding the threshold that will be needed to classify longitudinal changes in tumor volume as medically meaningful surrogates for changes in health status. 
 
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:* Compare the sensitivity of volumetric measurements to RECIST/ World Health Organization (WHO) (conventional & modified) outcome measures. 
 
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:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with volumetric techniques than with uni- or bi-dimensional line-lengths placed on a single slice.
 
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In a graphic, therapy assessment looks like this (this slide and the two following courtesy R. Avila):'''
 
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[[Image:Therapy Assessment.jpg]]
 
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'''The present defacto standard applies the following methodolgy:'''
 
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[[Image:RECIST Baseline.jpg]]
 
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'''Our goals are to address bias and variance, which in turn outght to allow shorter trials and/or lower enrollments:'''
 
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[[Image:We Can Do Better.jpg]]
 
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'''To accomplish this,''' we adopt the following flow which represents the structure of our effort as well as the resulting output we achieve:
 
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[[Image:QIBA Process for VolCT.jpg]]
 
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==Project Snapshot==
 
==Project Snapshot==
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*[[Media:Work breakdown for volCT-formatted.doc| Work Breakdown for Volumetric CT]] ''07.12.10''
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*[[Media:2008.09.15.Validation_Roadmap_VOL-CT_Image_Analysis.pdf|Validation Roadmap - P. David Mozley, MD]]
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*[[Media:Mr ODonnell QIBA Process Roadmap 20090629.ppt.pdf|Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629]]
  
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'''[[Quantitative Response Metrics for Lung Cancer]]''' was selected as a useful concrete focus to get started.
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==Meetings / Call Summaries==
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*[[Call Summaries]]
  
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===QIBA Profiles===
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==Profile Development==
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Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
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*[[Media: 2011.01.09.QIBA_VIA_Profile_V1_5.docx|VIA Profile v1.5]] ''01-09-2011''
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*[[Media: 2010.09.09.UPICT_CT_Lung_Nodule_V1_4a.cleaner copy.doc|VIA Protocol v1.4]] ''9-11-2010''
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* [[What Are Profiles?]]
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* [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF80Y253N3o3aGY&hl=en| UPICT Template for CT Lung Neoadjuvant WoOp Protocol V0.2] ''Posted 12/2009''
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* [[Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites]] ''Last updated 6/2009''
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* [[Profile: CT Lung Nodule Volume Change for Primary, Hilar and Medistinal Lymph Nodes]]
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* [[Profile: CT Lung Nodule Response]]
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* [[Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting]]
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* [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF8zcHFkdnhqY3A&hl=en| UPICT Template for CT Lung Nodule Protocol] ''Work in Progress''
  
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==Working Documents==
 
* [[Profile Strategy for Vol CT]]
 
* [[Profile Strategy for Vol CT]]
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** [[Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites]]
 
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** [[Profile: CT Lung Nodule Volume Change for Primary, Hilar and Medistinal Lymph Nodes]]
 
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** [[Profile: CT Lung Nodule Response]]
 
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** [[Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting]]
 
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**
 
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** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF8zcHFkdnhqY3A&hl=en| UPICT Template for CT Lung Nodule Protocol] ''Work in Progress''
 
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** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF80Y253N3o3aGY&hl=en| UPICT Template for CT Lung Neoadjuvant WoOp Protocol V0.2] ''Posted 12/2009''
 
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* [[Profile Template]] - still evolving
 
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* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is very analagous to our profiling work and addresses many similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
 
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===Groundwork Activities===
 
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Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
 
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* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
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* [[VolCT - Group 2]] - Set Standards for using Volumetric Imaging in Clinical Trials
 
* [[VolCT - Group 2]] - Set Standards for using Volumetric Imaging in Clinical Trials
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*[[Media:2008.12.16.Sources_of_Variability_-_Andrew_Buckler.xls|Sources of Variability - Andrew Buckler]]
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==Working Documents==
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*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
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*[[Media:2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors.long version.doc|2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors - long version]]
 
*[[Media:2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors.long version.doc|2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors - long version]]
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*[[Media:Work breakdown for volCT-formatted.doc| Work Breakdown for Volumetric CT]] ''07.12.10''
 
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* [[Initial Target Selection]] - describing the early prioritization discussions and settling on Lung Tumor Volumes
 
* [[Initial Target Selection]] - describing the early prioritization discussions and settling on Lung Tumor Volumes
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*[[Media:2008.12.16.Sources_of_Variability_-_Andrew_Buckler.xls|Sources of Variability - Andrew Buckler]]
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'''[[:Category:Datasets| See the Datasets page]]''' of the [[Catalog|QIBA Resource Catalog]]
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*[[Media:2008.09.15.Validation_Roadmap_VOL-CT_Image_Analysis.pdf|Validation Roadmap - P. David Mozley, MD]]
 
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*[[Media:2008.09.13-QIBA_Process-Groundwork_and_Profiling_Kevin_ODonnell.pdf|Process Groundwork & Profiling - Kevin O'Donnell]] - See also the '''[[Groundwork and Profiling|Wiki Version]]'''
 
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*[[Media:VolCTMatrix-Strawman-ver5-20090915.xls|Vol-CT Matrix (v5) 20090915]]
 
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==Reference Materials==
 
*Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
 
*Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
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* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses  similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
 
*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
 
*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
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*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
 
*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
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* [[What Are Profiles?]]
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==Slide Presentations==
 
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*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
 
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*[[Media:Mr ODonnell QIBA Process Roadmap 20090629.ppt.pdf|Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629]]
 
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==MSK Coffee Break Image Sets==
 
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'''[[:Category:Datasets| See the Datasets page]]''' of the [[Catalog|QIBA Resource Catalog]]
 
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==Meetings / Call Summaries==
 
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*[[Call Summaries]]
 

Revision as of 13:53, 9 January 2011

Project Snapshot

Meetings / Call Summaries

Profile Development

Working Documents

See the Datasets page of the QIBA Resource Catalog

Reference Materials

  • Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
  • Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
  • Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
  • Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology
  • What Are Profiles?
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