Difference between revisions of "CT Volumetry Biomarker Ctte"

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__NOTOC__
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{{TOCright}}
This Wiki is for collaborative creation of QIBA's Volumetric CT Technical Committee materials and ongoing activities.
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:Co-chairs: Rudresh Jarecha, MBBS, DNB, DMRE; Ehsan Samei, PhD and TBD
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:RSNA Staff Support: Julie Lisiecki
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* [http://tinyurl.com/QIBA-CT-Vol-Roster Roster]
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* [https://docs.google.com/spreadsheets/d/1qbBHaJNTAqHnAcmCTHsNfDph7hMyJ3NoUjYSdilVw8w/edit#gid=267283460 Attendance & Voting Privileges]
  
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==Meetings==
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* Tcons are held periodically. Contact RSNA Staff for details.
  
'''Mission''': Investigate the technical feasibility and medical value of quantifying longitudinal changes in volume with CT. 
 
  
'''Initial Objectives''':
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'''Recent Call Summaries:'''
:* Characterize the precision and accuracy of volumetric tumor measurements. 
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*[[Media:06 17 2021 QIBA CT Volumetry BC Call-FINAL.pdf|06.17.2021 QIBA CT Volumetry BC Call Summary]]
:: This will be an essential prelude for understanding the threshold that will be needed to classify longitudinal changes in tumor volume as medically meaningful surrogates for changes in health status.
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*[[Media:05 06 2021 QIBA CT Volumetry BC Call-FINAL.pdf|05.06.2021 QIBA CT Volumetry BC Call Summary]]
:* Compare the sensitivity of volumetric measurements to RECIST/ World Health Organization (WHO) (conventional & modified) outcome measures. 
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:: This will be necessary in order to determine if Progressive Disease can be detected significantly sooner with volumetric techniques than with uni- or bi-dimensional line-lengths placed on a single slice.
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*[[Media:07 23 2020 QIBA CT Volumetry BC Call-FINAL.pdf|07.23.2020 QIBA CT Volumetry BC Call Summary]]
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*[[Media:06 02 2020 QIBA CT Volumetry TF Call-FINAL.pdf|06.02.2020 QIBA CT Volumetry TF Call Summary]]
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*[[Media:04 30 2020 QIBA CT Volumetry Tf Call-FINAL.pdf|04.30.2020 QIBA CT Volumetry TF Call Summary]]
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*[[Media:03 12 2020 QIBA CT Volumetry BC Call-FINAL.pdf|03.12.2020 QIBA CT Volumetry Call Summary]]
  
In a graphic, therapy assessment looks like this (this slide and the two following courtesy R. Avila):'''
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'''''[[CT Volumetry BC Call Summaries Archive]]'''''
  
[[Image:Therapy Assessment.jpg]]
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==Profile Development==
  
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===Advanced Disease/Tumor Volume Change Profile===
  
'''The present defacto standard applies the following methodolgy:'''
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'''Status - Technical Confirmation in Ballot'''
  
[[Image:RECIST Baseline.jpg]]  
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*[[Media:QIBA_CTVol_TumorVolumeChangeProfile_DraftTechConfirmed-20180511-changetracked.docx | CT Tumor Volume Change Profile - Change tracked]] ''BALLOT DRAFT 2018.05.11''
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** This document shows all changes between the published Consensus Profile and the Ballot for Technically Confirmed.
  
  
'''Our goals are to address bias and variance, which in turn outght to allow shorter trials and/or lower enrollments:'''
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Past and Future
 
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:* [[Archived Versions#Advanced_disease|Archived Versions]] of Profile-related documents.
[[Image:We Can Do Better.jpg]]  
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:* [[CTV-AD Considerations for Future Editions|Considerations for Future Editions of CTV-AD]]
 
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'''To accomplish this,''' we adopt the following flow which represents the structure of our effort as well as the resulting output we achieve:
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[[Image:QIBA Process for VolCT.jpg]]
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==Project Snapshot==
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'''[[Quantitative Response Metrics for Lung Cancer]]''' was selected as a useful concrete focus to get started.
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===Profiling Activities===
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Write Profile documents to which equipment and sites can conform to accomplish Quantification goals.
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* [[What Are Profiles?]]
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* [[Profile Strategy for Vol CT]]
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** [[Profile: CT Lung Nodule Volume Measurement for Primary/Regional Nodes and Metastatic Sites]]
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** [[Profile: CT Lung Nodule Volume Change for Primary, Hilar and Medistinal Lymph Nodes]]
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** [[Profile: CT Lung Nodule Response]]
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** [[Profile: CT Lung Nodule - Small Nodule in Neoadjuvant Setting]]
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**
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** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF8zcHFkdnhqY3A&hl=en| UPICT Template for CT Lung Nodule Protocol] ''Work in Progress''
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** [http://docs.google.com/Doc?docid=0ASSwlnzdbPEGZHJyc2pxcF80Y253N3o3aGY&hl=en| UPICT Template for CT Lung Neoadjuvant WoOp Protocol V0.2] ''Posted 12/2009''
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* [[Profile Template]] - still evolving
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* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is very analagous to our profiling work and addresses many similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
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===Groundwork Activities===
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Validate key concepts and answer key questions needed to write the Profiles and demonstrate their effectiveness.
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==Groundwork Projects==
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These projects investigate (and resolve) scientific questions underlying QIBA Profile work.
 
* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1A]] - Analyze Bias/Variance where Ground Truth is Known Deterministically
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1B]] - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings  
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
 
* [[VolCT - Group 1C]] - Model Sources of Variability from a Systems Engineering Analysis
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* [[VolCT - Group 3A]] - Characterize variability due to algorithms (using phantoms / clinical data)
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* [[VolCT - Group 3B]] - Characterize clinical utility/efficacy with respect to clinical endpoints
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* [[VolCT - Colorado Group]] - Quantifying variability in measurement of pulmonary nodule
  
* [[VolCT - Group 2]] - Set Standards for using Volumetric Imaging in Clinical Trials
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*[[Media:NIBIB-2 Proposal for CT Volumetry 16APR2012.pdf|NIBIB-2 Proposal for CT Volumetry]]''16-APR-2012''
  
==Working Documents==
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==Reference Materials==
  
*[[Media:CT specifics - early draft.ppt|Early draft of "Why QIBA: CT Specifics"]]
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'''2012'''
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*Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
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**[[Media:ATCC is an independent private nonprofit 7-3-12.pdf|ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.]]
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*[[Media:Why_QIBA_CT_specifics.pdf|"Why QIBA?" - Specifics associated with CT device and software manufacturers.]]
  
*[[Media:2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors.long version.doc|2009 12 31 Review of Volumetric Image Analysis in Patients with Solid Tumors - long version]]
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'''2011'''
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*Dr Petrick's 2011 SPIE Presentation Materials
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*[[Media:Spie2011 NP QIBA1A-Talk-v05-final-1.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk]]
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*[[Media:Spie2011 NP QIBA1A-Paper-v08-final-2.pdf|“Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper]]
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*Compliance Documents: [[Media:Approach to Compliance 2011 08 15.pdf|QIBA Approach to Compliance-- ''Andrew J. Buckler, MS, Program Director, QIBA 08.15.11'']]
  
*[[Media:Work breakdown for volCT-formatted.doc| Work Breakdown for Volumetric CT]] ''07.12.10''
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'''2010'''
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*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
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*[[Media: Plan as of 11-8-10.jpg|Project plan]] ''.jpg version as of 11-8-10''
  
* [[Initial Target Selection]] - describing the early prioritization discussions and settling on Lung Tumor Volumes
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==Reference Articles==
*[[Media:2008.12.16.Sources_of_Variability_-_Andrew_Buckler.xls|Sources of Variability - Andrew Buckler]]
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*Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
*[[Media:2008.09.15.Validation_Roadmap_VOL-CT_Image_Analysis.pdf|Validation Roadmap - P. David Mozley, MD]]
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* [http://radiology.rsnajnls.org/cgi/content/full/243/2/527#T2 Radiology 2007 - Coronary Calcium Scoring] - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses  similar issues (e.g. achieving "standard" noise levels).  It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
*[[Media:2008.09.13-QIBA_Process-Groundwork_and_Profiling_Kevin_ODonnell.pdf|Process Groundwork & Profiling - Kevin O'Donnell]] - See also the '''[[Groundwork and Profiling|Wiki Version]]'''
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*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
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*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
  
*[[Media:VolCTMatrix-Strawman-ver5-20090915.xls|Vol-CT Matrix (v5) 20090915]]
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*[[Archive - Initial Target Selection and Roadmap]]
  
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==QIBA Funded Projects==
  
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'''Round 1'''
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*[[Duke University]]
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*[[Columbia University Medical Center]]
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*[[University of Colorado Denver, Department of Radiology]]
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*[[David Geffen School of Medicine at UCLA, Department of Radiology]]
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*[[CoreLab Partners, Inc.]]
  
*Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. [http://www.academicradiology.org/issues/contents?issue_key=S1076-6332(09)X0002-4 Academic Radiology]
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'''Round 2'''
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*[[CoreLab Partners, Inc., Round-2]]
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*[[David Geffen School of Medicine at UCLA, Department of Radiology,Round-2]]
  
*Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. [http://www.academicradiology.org/article/S1076-6332(08)00499-6/abstract Academic Radiology]
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'''Round 3'''
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*[[Media:Second 3A Statistical and Image Processing Analysis.pdf | Project (F) Second 3A Statistical and Image Processing Analysis (Elucid Bioimaging Inc.)]]
  
*Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. [http://www.academicradiology.org/article/S1076-6332(08)00530-8/abstract Academic Radiology]
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'''Round 4'''
 
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*[[Media:Methodology and Reference Image Set for Volumetric Characterization and Compliance.pdf | Project (Q) Phantoms Methodology and Reference Image Set for Volumetric Characterization and Compliance (Duke University)]]
==Slide Presentations==
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*[[Media:Quantification in Imaging-Dr Dirk Colditz-20100823.ppt|Quantification in Imaging-Dr Dirk Colditz]] ''August 23, 2010''
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*[[Media:Mr ODonnell QIBA Process Roadmap 20090629.ppt.pdf|Thoughts on the QIBA Process: Profiles, UPICT & Measurements by Kevin O’Donnell-20090629]]
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==MSK Coffee Break Image Sets==
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*[[Media:Phantoms for CT Volumetry of Hepatic and Nodal Metastasis.pdf | Project (S) Phantoms for CT Volumetry of Hepatic and Nodal Metastasis (CUMC)]]
  
'''[[:Category:Datasets| See the Datasets page]]''' of the [[Catalog|QIBA Resource Catalog]]
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'''Round 5'''
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*[[Media:Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization.pdf | Project (C) Reference Image Set for Quantitation Conformance of Algorithmic Lesion Characterization (Duke University)]]
  
==Meetings / Call Summaries==
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'''Round 6'''
*[[Call Summaries]]
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*[[Media:Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology.pdf | Project (S) Methodology and Reference Image Set for Lesion Characterization in Terms of Texture and Morphology (Duke University)]]

Revision as of 14:06, 17 June 2021

Co-chairs: Rudresh Jarecha, MBBS, DNB, DMRE; Ehsan Samei, PhD and TBD
RSNA Staff Support: Julie Lisiecki

Meetings

  • Tcons are held periodically. Contact RSNA Staff for details.


Recent Call Summaries:

CT Volumetry BC Call Summaries Archive

Profile Development

Advanced Disease/Tumor Volume Change Profile

Status - Technical Confirmation in Ballot


Past and Future

Groundwork Projects

These projects investigate (and resolve) scientific questions underlying QIBA Profile work.

  • VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
  • VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
  • VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
  • VolCT - Group 3A - Characterize variability due to algorithms (using phantoms / clinical data)
  • VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints
  • VolCT - Colorado Group - Quantifying variability in measurement of pulmonary nodule

Reference Materials

2012

2011

2010

Reference Articles

  • Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
  • Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
  • Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
  • Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

QIBA Funded Projects

Round 1

Round 2

Round 3

Round 4

Round 5

Round 6