CT Volumetry Biomarker Ctte

Co-chairs: Gregory Goldmacher, MD, PhD, MBA; Jenifer Siegelman, MD, MPH; Ehsan Samei, PhD

Secretary: Julie Lisiecki

• Roster

Meetings

• Tcons are held roughly Weekly. Contact the secretary for details.
• Call Summaries
• 10.16.2017 QIBA CT Volumetry Call Summary
• 10.02.2017 QIBA CT Volumetry Call Summary
• 09.11.2017 QIBA CT Volumetry Call Summary
• 08.28.2017 QIBA CT Volumetry Call Summary
• 08.07.2017 QIBA CT Volumetry Call Summary
• 07.17.2017 QIBA CT Volumetry Call Summary

Call Summaries Archive''

Profile Development

Advanced Disease/Tumor Volume Change Profile

Status - Consensus Profile complete

• QIBA Profile: CT Tumor Volume Change Profile CONSENSUS 2016.11.21b

• Checklist - CT Tumor Volumetry for Advanced Disease Field Trial v1.0

Status - Technical Confirmation in progress

• CT Tumor Volume Change Profile - PostConsensus DRAFT 2017.04.03
• Technical Confirmation Results and Resolutions - ONGOING WORK

• Columbia Volume repeatability assessment - Coming Soon

• Columbia Scan Protocol

Past and Future

• Archived Versions of Profile-related documents.
• Considerations for Future Editions of CTV-AD

Lung Nodule Assessment in CT Screening Profile

Status - Final Review in progress

• QIBA Lung Nodule Profile Comment Response 2017.10.07
• QIBA Lung Nodule Profile Draft 2017.09.27

Supporting documents:

• Ref3_SPIE 2017 Proceedings
• Ref5_Avila_et al_IWCLC Tape QA Abstract
• Ref6_Avila_etal_WCTI Hot Topic Abstract
• Ref7_Avila_et al_A Novel Ultra Low Cost CT Image Quality Measurement Dev
• Ref8_Avila_et al_Automatic Estimation of Measurement Error on CT Imaging

• QIBA Lung Nodule Profile Draft 2017.08.02

• Comments on mid-May draft from Kevin 2017.06.06

Status - Public Comment complete

• QIBA Profile: CT Lung Nodule Assessment in Screening Public Comment 2016.06.01 (ended Sept 2016)

• Spreadsheet: Small Nodule Profile References_Accuracy
• Spreadsheet: Small Nodule Profile References_Precision

Past

• Archived Versions of Profile-related documents.

Groundwork Projects

These projects investigate (and resolve) scientific questions underlying QIBA Profile work.

• VolCT - Group 1A - Analyze Bias/Variance where Ground Truth is Known Deterministically
• VolCT - Group 1B - Focus on Volume Change Analysis of Pulmonary Nodules in Diagnostic Settings
• VolCT - Group 1C - Model Sources of Variability from a Systems Engineering Analysis
• VolCT - Group 3A - Characterize variability due to algorithms (using phantoms / clinical data)
• VolCT - Group 3B - Characterize clinical utility/efficacy with respect to clinical endpoints
• VolCT - Colorado Group - Quantifying variability in measurement of pulmonary nodule

• NIBIB-2 Proposal for CT Volumetry16-APR-2012

Reference Materials

2012

• Dr Mulshine's Presentation Materials from July 2nd adapted from the ATCC Website
  • ATCC is an independent, private, nonprofit biological resource center (BRC) and research organization.
• "Why QIBA?" - Specifics associated with CT device and software manufacturers.

2011

• Dr Petrick's 2011 SPIE Presentation Materials
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Talk
• “Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging” - Paper
• Compliance Documents: QIBA Approach to Compliance-- Andrew J. Buckler, MS, Program Director, QIBA 08.15.11

2010

• Quantification in Imaging-Dr Dirk Colditz August 23, 2010
• Project plan .jpg version as of 11-8-10

Reference Articles

• Are we ready? A time for measurement of physiological parameters of the lung using multidetector row CT scans. Hatabu H. Acad Radiol. 2009 Mar; 16(3):249. Academic Radiology
• Radiology 2007 - Coronary Calcium Scoring - This paper by Dr. McCollough et al is may be seen to be analaogous to our work in that it addresses similar issues (e.g. achieving "standard" noise levels). It could be thought of as an early draft of a Calcium Scoring profile, including both groundwork and equipment specifications.
• Helical multidetector row quantitative computed tomography (QCT) precision. Bligh M, Bidaut L, White RA, Murphy WA Jr, Stevens DM, Cody DD. Acad Radiol. 2009 Feb; 16(2):150-9. Academic Radiology
• Comparison of the accuracy of CT volume calculated by circumscription to prolate ellipsoid volume (bidimensional measurement multiplied by coronal long axis). Rkein AM, Harrigal C, Friedman AC, Persky D, Krupinski E. Acad Radiol. 2009 Feb; 16(2):181-6. Academic Radiology

• Archive - Initial Target Selection and Roadmap

QIBA Funded Projects

Round 1

• Duke University
• Columbia University Medical Center
• University of Colorado Denver, Department of Radiology
• David Geffen School of Medicine at UCLA, Department of Radiology
• CoreLab Partners, Inc.

Round 2

• CoreLab Partners, Inc., Round-2
• David Geffen School of Medicine at UCLA, Department of Radiology,Round-2