Difference between revisions of "VolCT - Group 1A"
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+ | ==Current Goals & Status:== | ||
+ | |||
+ | * Goal: Benchmark intra/inter-reader variability for lung nodule volume measurements | ||
+ | ** Status: Most of Dataset acquired; finalizing reader software | ||
+ | ** Related Profile: | ||
+ | |||
+ | |||
+ | == Work Documents == | ||
*[[Vol-CT - 1A Group Call Summaries]] | *[[Vol-CT - 1A Group Call Summaries]] | ||
*[[Media:Qiba-nxp-ProposedPhase1A-2008-11-13-v05.ppt|Proposed 1A Protocol Outline (2008-11-13-v05)- For Comment from QIBA Members]] | *[[Media:Qiba-nxp-ProposedPhase1A-2008-11-13-v05.ppt|Proposed 1A Protocol Outline (2008-11-13-v05)- For Comment from QIBA Members]] | ||
+ | |||
+ | == Projects == | ||
+ | ''May want to split these out to separate pages later'' | ||
+ | |||
+ | ===VolCT Lung Anthropomorphic Phantom Study=== | ||
+ | |||
+ | ====Objective: ==== | ||
+ | Measure intra- & inter-reader bias and variability phantom lesions for: | ||
+ | :* Uni-dimensional size measurement | ||
+ | :* Semi-automatic 3D volumetric measure | ||
+ | |||
+ | May compare with fully automated algorithm(s) | ||
+ | |||
+ | ====Dataset:==== | ||
+ | Ground truth has been established by physical measurement "ex vivo“ on FDA phantom inserts. | ||
+ | |||
+ | Nodules (10 attached nodules) | ||
+ | :* -10 & +100HU | ||
+ | :* 10, 20 mm spheres | ||
+ | :* 10 mm ovoid, lobulated, spiculated | ||
+ | |||
+ | Image Dataset | ||
+ | :* 100 mAs exposures | ||
+ | :* 0.75 & 5.0 mm slices | ||
+ | :* 1 recon kernel | ||
+ | :* Status: | ||
+ | :** mostly acquired by FDA/CDRH/OSEL. | ||
+ | :** Missing: 10 mm ovoid, spic, lob (Est: 12/01/08) | ||
+ | |||
+ | Acquisition Protocol: | ||
+ | :* Scanner: Philips 16 slice | ||
+ | :* Exposure (120 kVp): 100 mAs | ||
+ | :* Slice thickness (50% overlap): 0.75 & 5.0 mm slices | ||
+ | :* Recon kernel: Standard/medium (Still on table: Detail/Lung kernel) | ||
+ | :* Pitch: 1.2 | ||
+ | :* 2 repeat scans | ||
+ | :* 40 segmentations in set | ||
+ | |||
+ | The study is being conducted as a pilot. The size (data, readers) has not been selected for any specific level of significance. | ||
+ | |||
+ | ====Study Protocol:==== | ||
+ | Expert readers will measure/estimate nodule size from CT images. | ||
+ | |||
+ | Readers: 6 RadPharm radiologists | ||
+ | |||
+ | Software: | ||
+ | :* ''Wendy will visit RadPharm and provide more info next week'' | ||
+ | :* In-house review software (Siemens?) | ||
+ | :** Semi-automated 3D volume software | ||
+ | :** Uni-dimensional measure (RESIST) | ||
+ | :* ''Which fully automated software?'' | ||
+ | |||
+ | Reading Session: | ||
+ | :* Readers read all cases in 2 different reading sessions | ||
+ | :** Random ordering | ||
+ | :*** One-dimensional measure | ||
+ | :*** Semi-automated segmentation | ||
+ | :** Sessions separated by 3 week(?) | ||
+ | :** Include duplicate cases within each read session (1/3-1/2 of cases for intra-reader estimates) | ||
+ | :* Time restrictions: Probably not (?) | ||
+ | :* Specific instructions: Probably not (?) | ||
+ | |||
+ | ====Analysis:==== | ||
+ | Estimate intra- and inter-reader variability in the different volume estimate | ||
+ | :* Estimate bias from known truth | ||
+ | :* Estimate variability | ||
+ | |||
+ | Compare the bias and variability with the different methods | ||
+ | |||
+ | ====Outstanding Issues:==== |
Revision as of 22:38, 11 December 2008
Current Goals & Status:
- Goal: Benchmark intra/inter-reader variability for lung nodule volume measurements
- Status: Most of Dataset acquired; finalizing reader software
- Related Profile:
Work Documents
- Vol-CT - 1A Group Call Summaries
- Proposed 1A Protocol Outline (2008-11-13-v05)- For Comment from QIBA Members
Projects
May want to split these out to separate pages later
VolCT Lung Anthropomorphic Phantom Study
Objective:
Measure intra- & inter-reader bias and variability phantom lesions for:
- Uni-dimensional size measurement
- Semi-automatic 3D volumetric measure
May compare with fully automated algorithm(s)
Dataset:
Ground truth has been established by physical measurement "ex vivo“ on FDA phantom inserts.
Nodules (10 attached nodules)
- -10 & +100HU
- 10, 20 mm spheres
- 10 mm ovoid, lobulated, spiculated
Image Dataset
- 100 mAs exposures
- 0.75 & 5.0 mm slices
- 1 recon kernel
- Status:
- mostly acquired by FDA/CDRH/OSEL.
- Missing: 10 mm ovoid, spic, lob (Est: 12/01/08)
Acquisition Protocol:
- Scanner: Philips 16 slice
- Exposure (120 kVp): 100 mAs
- Slice thickness (50% overlap): 0.75 & 5.0 mm slices
- Recon kernel: Standard/medium (Still on table: Detail/Lung kernel)
- Pitch: 1.2
- 2 repeat scans
- 40 segmentations in set
The study is being conducted as a pilot. The size (data, readers) has not been selected for any specific level of significance.
Study Protocol:
Expert readers will measure/estimate nodule size from CT images.
Readers: 6 RadPharm radiologists
Software:
- Wendy will visit RadPharm and provide more info next week
- In-house review software (Siemens?)
- Semi-automated 3D volume software
- Uni-dimensional measure (RESIST)
- Which fully automated software?
Reading Session:
- Readers read all cases in 2 different reading sessions
- Random ordering
- One-dimensional measure
- Semi-automated segmentation
- Sessions separated by 3 week(?)
- Include duplicate cases within each read session (1/3-1/2 of cases for intra-reader estimates)
- Random ordering
- Time restrictions: Probably not (?)
- Specific instructions: Probably not (?)
- Readers read all cases in 2 different reading sessions
Analysis:
Estimate intra- and inter-reader variability in the different volume estimate
- Estimate bias from known truth
- Estimate variability
Compare the bias and variability with the different methods