VolCT - Group 1B
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Current Goals & Status:
Question: What is the minimum detectable level of change in patient datasets under a “No Change” condition?
- AIMS: For patient datasets acquired over a very short time interval (“no change” condition”) investigate variance in measuring change in volume, diameter and bi-directional diameters of lesions
- Investigate inter-observer variability in each task
- Investigate Intra-observer variability in each task
- Methods - Materials
- Image Data from MSK Coffee Break Experiment
- 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes
- Thin slice (1.25 mm thick) image data
- Selected one lesion per patient
- no outcome data
- Publicly Available on TCIA
- Methods - Materials
- Methods - Readings
- 5 readers
- Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability
- Methods - Measurements
- Measure Single Longest Diameter, manually (SLD)
- Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD)
- Contour Full Boundary of lesion with semiautomated tool; calculate volume (Vol)
- Extract other measures as well (SLD from POD measureement; SLD from VOl and POD from Vol).
- The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10)
- Methods - Readings
- Analyses
- Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method
- Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray
- Analyses
- Analysis Reports
- Exp 1B Coffee Break Descriptive Statistics - 24Sep2010
- QIBA_Exp1B_Coffee Break Summary Table_26Jan11_RECIST_Measureable_or_NOT
- Exp 1B Coffee Break Descriptive Statistics - 25Mar2011_Subjective Assessments_EZ_mod_diff**
- QIBA_Exp1B_CoffeeBreak_summaryTable_minimum Detectable Change_ 18Apr2011
- Methods Related Documents
- QIBA_Exp1b_Coffee_Break_List of lesions with coordinates and pictures
- Naming Convention for the QIBA Group 1B Experiment and randomization scheme
- Other Related Documents
- Related Profile: Lung Vol Quantification - Measurement Activity
- Proposed Group 1B Questions & Datases (2009-02-10) -- Feedback Welcome -- Dr. McNitt-Gray
- ACRIN 6678 Quality Control Parameters for CT Scan Tumor Volumetric Measurements
- Conference Poster on Reproducibility and Accuracy of Uni- and Bi-Dimensional Tumor Measurements from MRI and CT Volumes, which looks at RECIST, WHO and Volume measurements.
Downloadable Images and Data Sets
Round 2 Images and Results
- TCIA - RIDER Lung CT Images - (MSKCC Coffee Break) - Used as No Change Cases link posted 12.29.2012 updated 05.24.2023
- TCIA (formerly at NBIA) - RIDER Pilot CT Images - Used as With Change Distractors link posted 12.29.2012 updated 05.24.2023
- DICOM Result Files (SR,SEG,PR) posted 12.29.2012 - now also at TCIA QIBA VolCT Group 1B Round 2 No Change Size Measurements (QIBA-VolCT-1B) posted 05.24.2023
- Release notes describing collection contents posted 12.29.2012
- Description of SR encoding template posted 12.29.2012
- Excel File describing "No Change" cases (filenames, slice location, x,y coordinates, etc.)
- Excel File describing "Change" cases (filenames, slice location, x,y coordinates, etc.)
- Tabulated reader results version 08.12.2012 posted 02.05.2013
Round 1 Images and Results
- Tabulated reader results version 08.04.2010 posted 02.05.2013