Difference between revisions of "VolCT - Group 1B"
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** Investigate Intra-observer variability in each task | ** Investigate Intra-observer variability in each task | ||
− | ** Methods - Materials | + | ** '''Methods - Materials''' |
*** Image Data from MSK Coffee Break Experiment | *** Image Data from MSK Coffee Break Experiment | ||
*** 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes | *** 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes | ||
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*** Publicly Available on NCIA | *** Publicly Available on NCIA | ||
− | ** Methods - Readings | + | ** '''Methods - Readings''' |
*** 5 readers | *** 5 readers | ||
*** Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability | *** Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability | ||
− | ** Methods - Measurements | + | ** '''Methods - Measurements''' |
*** Measure Single Longest Diameter, manually (SLD) | *** Measure Single Longest Diameter, manually (SLD) | ||
*** Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD) | *** Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD) | ||
Line 24: | Line 24: | ||
** The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10) | ** The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10) | ||
− | ** Analyses | + | ** ''' Analyses''' |
*** Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method | *** Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method | ||
*** Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray | *** Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray |
Revision as of 06:02, 20 April 2011
Current Goals & Status:
- Question: What is the minimum detectable level of change in patient datasets under a “No Change” condition?
- AIMS: For patient datasets acquired over a very short time interval (“no change” condition”) investigate variance in measuring change in volume, diameter and bi-directional diameters of lesions
- Investigate inter-observer variability in each task
- Investigate Intra-observer variability in each task
- Methods - Materials
- Image Data from MSK Coffee Break Experiment
- 32 NSCLC patients, imaged twice on same scanner over period < 15 minutes
- Thin slice (1.25 mm thick) image data
- Selected one lesion per patient
- no outcome data
- Publicly Available on NCIA
- Methods - Materials
- Methods - Readings
- 5 readers
- Read CT at timepoint 1, CT at timepoint 2 and repeat either CT timepoint 1 or timeoint 2 to assess intra-reader variability
- Methods - Measurements
- Measure Single Longest Diameter, manually (SLD)
- Measure Longest Diameter and Perpendicular Diameter; take product to obtain Product of Diameters (POD)
- Contour Full Boundary of lesion with semiautomated tool; calculate volume (Vol)
- Extract other measures as well (SLD from POD measureement; SLD from VOl and POD from Vol).
- The Order of Readers, Lesions and Measurement Methods were Randomized (Measurements done in Blocks of 10)
- Methods - Readings
- Analyses
- Pooled Analysis across readers and lesions; Percent Difference between Scan 1 and Scan 2 for each measurement method
- Subgroup Analyses: (a) Based on Measureable/Non-Measureable lesions identified by Mike O'Neal of CoreLabs; (b) Difficult, Moderate and Easy as Identified by Mike McNitt-Gray
- Analyses
- Analysis Reports
- Exp 1B Coffee Break Descriptive Statistics - 24Sep2010
- QIBA_Exp1B_Coffee Break Summary Table_26Jan11_RECIST_Measureable_or_NOT
- Exp 1B Coffee Break Descriptive Statistics - 25Mar2011_Subjective Assessments_EZ_mod_diff**
- QIBA_Exp1B_CoffeeBreak_summaryTable_minimum Detectable Change_ 18Apr2011
- Methods Related Documents
- [[Media:|QIBA_Exp1b_Coffee_Break_List of lesions with coordinates and pictures]]
- Naming Convention for the QIBA Group 1B Experiment and randomization scheme
- Vol-CT - 1B Group Call Summaries
- Other Related Documents
- Related Profile: Lung Vol Quantification - Measurement Activity
- Proposed Group 1B Questions & Datases (2009-02-10) -- Feedback Welcome -- Dr. McNitt-Gray
- ACRIN 6678 Quality Control Parameters for CT Scan Tumor Volumetric Measurements
- Conference Paper on Reproducibility and Accuracy of Uni- and Bi-Dimensional Tumor Measurements from MRI and CT Volumes, which looks at RECIST, WHO and Volume measurements.