SPECT Biomarker Ctte

Co-chairs: Yuni Dewaraja, PhD; P. David Mozley, MD; John Seibyl, MD

Secretary: Julie Lisiecki

• Roster

Project Snapshot

The SPECT Biomarker Committee seeks to develop a quantitative imaging profile for SPECT imaging.

Under consideration:

• quantifying a small structure (like the basal ganglion in the DaTscan, thyroid)
• quantifying organs, like the liver, for dosimetry as potential use cases

Established Task Forces currently working toward a first Profile titled: Quantifying Dopamine Transporters with 123-Iodine labeled Ioflupane in Neurodegenerative Disease

• Image Acquisition and Image Processing for DaTscan – Dr. Dewaraja
• Quantitative / Image Analysis – Drs. Miyaoka and Seibyl
• Phantoms / DRO Group – Drs. Dickson and Zimmerman
• Clinical / Literature Review – Dr. Seibyl

Recent Meetings/Call Summaries

• SPECT Call Summaries

SPECT BC Call Summaries Archive

Literature Review (Profile 1.0)

• QIBA Literature Review Slides for Profile 1.0 - Dr. Seibyl March 22, 2016

• QIBA Literature Review for Profile 1.0 (Word document) - Dr. Seibyl March 22, 2016

Profile Development

• QIBA Profile: Quantifying Dopamine Transporters with 123 - Iodine Labeled Ioflupane in Neurodegenerative Disease Profile (v1.1), August 28, 2017

• QIBA Profile: Quantifying Dopamine Transporters with 123 - Iodine Labeled Ioflupane in Neurodegenerative Disease Profile (v1.1), June 26, 2017

• QIBA Profile: Quantifying Dopamine Transporters with 123 - Iodine Labeled Ioflupane in Neurodegenerative Disease Profile (v1.0), October 28, 2016

• QIBA Profile Checklist: SPECT Profile Conformance

• QIBA DRAFT Profile with tracked changes - {Dr. Miyaoka} May 10, 2016

• QIBA DRAFT Profile with tracked changes - {Dr. Dewaraja} May 1, 2016

• QIBA DRAFT Profile with tracked changes - {Dr. Mozley} April 15, 2016

• QIBA DRAFT Profile with tracked changes for recent additions and homework - {Dr. E. Frey} April 5, 2016

• Archived past versions of the Profile

Reference Materials

• QIBA SPECT TF presentation slides - Dr. Seibyl August 23, 2016

• QIBA SPECT BC presentation slides - Dr. Mozley July 15, 2016

• QIBA SPECT BC presentation slides - Dr. Miyaoka July 12, 2016

• QIBA SPECT BC presentation slides - Dr. Miyaoka May l0, 2016

• QIBA SPECT BC presentation slides - Dr. Dewaraja May 5, 2016

• QIBA SPECT BC presentation slides - Dr. Miyaoka April 22, 2016

• QIBA SPECT BC presentation slides - Dr. Seibyl March 8, 2016

• QIBA SPECT BC presentation slides - Dr. Frey February 2, 2016

• QIBA SPECT BC presentation slides - Dr. Buchert February 2, 2016

• QIBA SPECT BC presentation slides - Dr. Seibyl January 22, 2016

• Quantification and Image Analysis Task Force presentation slides - Dr. Miyaoka January 12, 2016

• Quantification and Image Analysis Task Force presentation slides - Dr. Seibyl January 12, 2016

• I-123 DAT SCAN - Acquisition and Reconstruction Task Force presentation slides - Dr. Dewaraja January 5, 2016

• Acquisition Processes for SPECT - Drs. Dewaraja, Frey, and Iida (notes) December 8, 2015

• System Variance Model for SPECT Ioflupane - Drs. Smith and Zeintl (Siemens) November 20, 2015

• QIBA Claim Statement Types - Dr. Obuchowski November 20, 2015

• 03.20.2015 Link to papers of the group in Umeå that are collaborating with Dr. Ljungberg:
• The PI for this is Anne Larsson, PhD: http://www.ncbi.nlm.nih.gov/pubmed/?term=dat+scan+Larsson+A