QIBA for Statisticians

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QIBA Mission: Improve the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time.

QIBA develops Profile documents that standardize methods for creating a specific biomarker with predictable performance (accuracy and reproducibility).


Statisticians benefit from QIBA by:

  • having good estimates of the technical performance of QIBs obtained using a given QIBA Profile
  • understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
  • understanding the role of technical performance characteristics in quantifying change in individual patients


Statisticians may also:

  • support testing of actors’ conformance
  • optimize study design in clinical trials with QIBs
  • determine sample size for clinical trials using QIBs
  • provide unbiased estimates of treatment effects when QIBs are endpoints

<First Steps>

  • Who to contact to get involved - qiba@rsna.org (provide staff with a list of "responder" volunteers for more in depth)
  • Document to start with?
  •  ???