QIBA for Statisticians

QIBA Mission: Improve the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time.

QIBA develops Profile documents that standardize methods for creating a specific biomarker with predictable performance (accuracy and reproducibility).

Statisticians benefit from QIBA by:

• understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
• understanding the role of technical performance characteristics in quantifying change in individual patients
• (being provided with good estimates of the technical performance of QIBs obtained using a given QIBA Profile)

Statisticians participate in QIBA Profiles by:

• supporting testing of actors’ conformance with requirements in a given QIBA Profile

Statisticians may also consider:

• optimizing study design in clinical trials with QIBs
• determining sample size calculations for clinical trials using QIBs
• providing unbiased estimates of treatment effects when QIBs are endpoints