Difference between revisions of "QIBA for Statisticians"

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Statisticians '''benefit''' from QIBA by:
 
Statisticians '''benefit''' from QIBA by:
 +
* having '''good estimates of the technical performance''' of QIBs obtained using a given QIBA Profile
 
* understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
 
* understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
 
* understanding the role of technical performance characteristics in quantifying change in individual patients
 
* understanding the role of technical performance characteristics in quantifying change in individual patients
* having access to '''good estimates of the technical performance''' of QIBs obtained using a given QIBA Profile
 
 
 
Statisticians '''participate''' in QIBA Profiles by:
 
* supporting testing of actors’ conformance with requirements in a given QIBA Profile
 
  
  
 
Statisticians '''may also''':
 
Statisticians '''may also''':
 +
* '''support testing''' of actors’ conformance
 
* '''optimize study design''' in clinical trials with QIBs  
 
* '''optimize study design''' in clinical trials with QIBs  
 
* '''determine sample size''' calculations for clinical trials using QIBs
 
* '''determine sample size''' calculations for clinical trials using QIBs
* provide unbiased estimates of treatment effects when QIBs are endpoints
+
* '''provide unbiased estimates''' of treatment effects when QIBs are endpoints

Revision as of 21:17, 15 October 2019

QIBA Mission: Improve the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time.

QIBA develops Profile documents that standardize methods for creating a specific biomarker with predictable performance (accuracy and reproducibility).


Statisticians benefit from QIBA by:

  • having good estimates of the technical performance of QIBs obtained using a given QIBA Profile
  • understanding the role of technical performance characteristics (repeatability, reproducibility, bias, linearity) in the study design and analysis of clinical trials with quantitative imaging biomarkers (QIBs)
  • understanding the role of technical performance characteristics in quantifying change in individual patients


Statisticians may also:

  • support testing of actors’ conformance
  • optimize study design in clinical trials with QIBs
  • determine sample size calculations for clinical trials using QIBs
  • provide unbiased estimates of treatment effects when QIBs are endpoints